Anoushka Mullasseril , Anh B. Lam , Alekhya Mitta , Daniel Morton , Andrew McIntosh , Sanjay Patel , Theresa Thai , Anand Annan , Adanma Ayanambakkam
{"title":"Spontaneous regression of metastatic clear cell renal cell carcinoma: A report of a rare case and a review of the literature","authors":"Anoushka Mullasseril , Anh B. Lam , Alekhya Mitta , Daniel Morton , Andrew McIntosh , Sanjay Patel , Theresa Thai , Anand Annan , Adanma Ayanambakkam","doi":"10.1016/j.eucr.2024.102868","DOIUrl":null,"url":null,"abstract":"<div><div>Renal cell carcinoma (RCC) is the seventh most common cancer in the United States; clear cell RCC (ccRCC) is the most common subtype. We report a case of spontaneous regression of metastatic ccRCC and discuss possible underlying mechanisms informed by a literature review. While regression of metastatic RCC has been described following nephrectomy or treatment of the primary tumor, spontaneous regression is rare. Postulated underlying causes include tumor necrosis and immune-mediated responses. Of 29 identified cases of spontaneous regression, only ours occurred after only a biopsy. Better understanding of the pathophysiology of spontaneous regression in RCC will improve its management.</div></div>","PeriodicalId":38188,"journal":{"name":"Urology Case Reports","volume":"57 ","pages":"Article 102868"},"PeriodicalIF":0.5000,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Urology Case Reports","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2214442024002225","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"UROLOGY & NEPHROLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Renal cell carcinoma (RCC) is the seventh most common cancer in the United States; clear cell RCC (ccRCC) is the most common subtype. We report a case of spontaneous regression of metastatic ccRCC and discuss possible underlying mechanisms informed by a literature review. While regression of metastatic RCC has been described following nephrectomy or treatment of the primary tumor, spontaneous regression is rare. Postulated underlying causes include tumor necrosis and immune-mediated responses. Of 29 identified cases of spontaneous regression, only ours occurred after only a biopsy. Better understanding of the pathophysiology of spontaneous regression in RCC will improve its management.
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