A review of the application of small organic molecule fluorescent probes in ischemia-reperfusion injury

IF 4.1 3区工程技术 Q2 CHEMISTRY, APPLIED Dyes and Pigments Pub Date : 2024-10-29 DOI:10.1016/j.dyepig.2024.112524

Xinfeng Zhang , Nazeer Muhammad Nouman , Caixia Yin , Fangjun Huo

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Abstract

Ischemia-reperfusion injury is closely linked to oxidative stress, which arises from the complicated metabolism of substances and energy. There is a growing inclination towards developing and applying fluorescent probe tools to explore this phenomenon's physiological and pathological mechanisms. Starting from the pathophysiology of ischemia-reperfusion injury in various organs, this review will provide a comprehensive overview of the research advancements related to developing and applying fluorescence probes for studying ischemia-reperfusion diseases. We will examine the use of small molecule fluorescence probes in the context of ischemia-reperfusion in various tissues and organs. Our focus will include liver, brain, kidney, and myocardial ischemia-reperfusion and other related conditions. In addition, this comment will deeply reflect on and analyze the development direction of fluorescent probes for ischemia-reperfusion injury, highlighting their potential for accurate clinical diagnosis and application research. This discussion aims to inspire hope and optimism in the audience about the future of medical research.

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有机小分子荧光探针在缺血再灌注损伤中的应用综述

缺血再灌注损伤与氧化应激密切相关，氧化应激源于复杂的物质和能量代谢。人们越来越倾向于开发和应用荧光探针工具来探索这一现象的生理和病理机制。本综述将从各器官缺血再灌注损伤的病理生理学入手，全面概述开发和应用荧光探针研究缺血再灌注疾病的相关研究进展。我们将研究小分子荧光探针在各种组织和器官缺血再灌注中的应用。我们的研究重点将包括肝、脑、肾和心肌缺血再灌注及其他相关疾病。此外，本评论还将深入思考和分析缺血再灌注损伤荧光探针的发展方向，突出其在临床精确诊断和应用研究方面的潜力。本次讨论旨在激发听众对未来医学研究的希望和乐观态度。

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来源期刊

Dyes and Pigments 工程技术-材料科学：纺织

CiteScore

8.20

自引率

13.30%

发文量

933

审稿时长

33 days

期刊介绍： Dyes and Pigments covers the scientific and technical aspects of the chemistry and physics of dyes, pigments and their intermediates. Emphasis is placed on the properties of the colouring matters themselves rather than on their applications or the system in which they may be applied. Thus the journal accepts research and review papers on the synthesis of dyes, pigments and intermediates, their physical or chemical properties, e.g. spectroscopic, surface, solution or solid state characteristics, the physical aspects of their preparation, e.g. precipitation, nucleation and growth, crystal formation, liquid crystalline characteristics, their photochemical, ecological or biological properties and the relationship between colour and chemical constitution. However, papers are considered which deal with the more fundamental aspects of colourant application and of the interactions of colourants with substrates or media. The journal will interest a wide variety of workers in a range of disciplines whose work involves dyes, pigments and their intermediates, and provides a platform for investigators with common interests but diverse fields of activity such as cosmetics, reprographics, dye and pigment synthesis, medical research, polymers, etc.