Michael I. McBurney , Nathan L. Tintle , Jason Westra , William S. Harris , Sharon E. Curhan
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引用次数: 0
Abstract
Background
Disabling hearing loss affects ∼430 million people globally. Fish consumption and long-chain n-3 polyunsaturated fatty acid (PUFA) intake were inversely associated with risk of hearing loss, but the association of plasma n-3 PUFAs and hearing loss is unclear.
Objective
To examine the associations between plasma n-3 PUFA fractions (as % of total fatty acids), i.e., DHA % and Other n-3 PUFA % (defined as total n-3 PUFA minus DHA), with self-reported hearing difficulty in a population-based cohort in the UK.
Methods
Our study includes 175,177 UK Biobank participants (40–69y, 54 % women) with data on plasma n-3 PUFA and hearing status. Baseline plasma PUFA levels were analyzed by nuclear magnetic resonance, and self-reported hearing difficulty was obtained by questionnaire between 2007 and 2010. Logistic regression was used to estimate age-adjusted odds ratios (ORs), multivariable-adjusted odds ratios (MVORs) by adjusting for 14 demographic, behavioral, biomarker and health-related potential confounders, and 95 % confidence intervals (CIs).
Results
Hearing difficulty was reported by 26.7 % of participants. Higher plasma n-3 PUFA levels were independently associated with lower odds of self-reported hearing difficulty. The prevalence of hearing difficulty rose across age strata (40–49y, 15.8 %; 50–59y, 24.9 % and 60+y, 34.4 %; p < 0.0001) and overall was higher in males (33.2 %) than females (21.3 %). Compared with those in the lowest quintile of plasma DHA % or Other n-3 PUFA %, the MVOR (95 % CI) for hearing difficulty was 0.88 (0.85, 0.92) in highest quintile of plasma DHA %, and 0.91 (0.87, 0.94) in the highest quintile of Other n-3 PUFA %. The associations with DHA % did not differ by age or sex (p-for-interaction 0.83 and 0.58, respectively). MVORs for DHA % and Other n-3 PUFA % were similar among the 44,486 individuals with data on noise exposure at work.
Conclusions
Higher plasma n-3 PUFA levels were independently associated with lower odds of hearing difficulty.
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