Single-Base Resolution Photonic-Integrated Chips via Hybrid Dielectric–Metal Nanocavities for Ultrasensitive Multichannel Biosensing

IF 6.5 1区 物理与天体物理 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY ACS Photonics Pub Date : 2024-11-06 DOI:10.1021/acsphotonics.4c01437
Bowen Du, Yule Zhang, Fuquan Xie, Zhi Chen, Songrui Wei, Yanqi Ge, Xilin Tian, Qiao Jiang, Qiuliang Wang, Xueji Zhang, Defa Li, Zhongjian Xie, Han Zhang
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Abstract

The development of highly precise and rapid biological photonic-integrated chips with single-base resolution for target gene detection holds immense potential to revolutionize genetic diagnostics and nonlinear optical devices. Our recent study presents the design of a single-base resolution photonic-integrated chip (SRPIC) with multichannel biosensing capabilities, enabling discrimination between gene segment sequences differing by a single nucleotide at sample concentrations below 1 fM. Through the utilization of hybrid dielectric–metal nanocavity arrays, the SRPIC established an efficient biosensing platform by motivating light-biological matter coupling behavior. This accomplishment represents an extraordinary 104-fold increase in the limit of detection (LOD) compared with the CRISPR-HOLMES technique, exhibiting nearly impeccable precision during clinical testing. Our research highlights the potential of SRPIC as a powerful tool for the development of high-performance photonic-integrated chips capable of achieving multichannel single-base resolution biosensing, with each channel representing the detection of a single virus.

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通过介电-金属混合纳米腔体实现超灵敏多通道生物传感的单基点分辨率光子集成芯片
开发具有单碱基分辨率的高精度、快速生物光子集成芯片用于目标基因检测,在基因诊断和非线性光学设备领域具有巨大的变革潜力。我们最近的研究介绍了一种具有多通道生物传感功能的单碱基分辨率光子集成芯片(SRPIC)的设计,它能在样品浓度低于 1 fM 的情况下,区分相差一个核苷酸的基因片段序列。通过利用混合介质-金属纳米腔阵列,SRPIC 利用光-生物物质耦合行为建立了一个高效的生物传感平台。与 CRISPR-HOLMES 技术相比,这一成果意味着检测限(LOD)提高了 104 倍,在临床测试中表现出近乎无可挑剔的精确度。我们的研究凸显了 SRPIC 的潜力,它是开发高性能光子集成芯片的有力工具,能够实现多通道单碱基分辨率生物传感,每个通道代表一种病毒的检测。
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来源期刊
ACS Photonics
ACS Photonics NANOSCIENCE & NANOTECHNOLOGY-MATERIALS SCIENCE, MULTIDISCIPLINARY
CiteScore
11.90
自引率
5.70%
发文量
438
审稿时长
2.3 months
期刊介绍: Published as soon as accepted and summarized in monthly issues, ACS Photonics will publish Research Articles, Letters, Perspectives, and Reviews, to encompass the full scope of published research in this field.
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