Life history dynamics of evolving tumors: insights into task specialization, trade-offs, and tumor heterogeneity.

IF 5.3 2区医学 Q1 ONCOLOGY Cancer Cell International Pub Date : 2024-11-06 DOI:10.1186/s12935-024-03538-4

Mahmoud Ahmed, Deok Ryong Kim

引用次数: 0

Abstract

The evolution of cancer cells parallels species evolution in numerous ways. Variations arise and spread under the pressure of competition between cancer cells. Current investigations of tumor evolution echo earlier debates between biologists. These include the role of non-Darwinian mechanisms, the contribution of neutral evolution, and life history dynamics. The trade-off between proliferation and metastasis is the most well-studied application of life history theory to cancer evolution. This article briefly introduces some parallels between cancer and species evolution, focusing on the life history of evolving tumors. Next, we review evidence from simulation and experimental studies supporting task specialization and trade-offs in cancer. We also cover recent work on inferring tumor tasks from data. We then turn to the implications of multi-tasking and the utility of the theory in explaining critical aspects of tumor heterogeneity. Finally, we discuss some of the criticism and future directions of this research topic.

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不断演变的肿瘤的生命史动态：对任务专业化、权衡和肿瘤异质性的见解。

癌细胞的进化在许多方面与物种进化相似。变异是在癌细胞之间竞争的压力下产生和扩散的。目前对肿瘤进化的研究与生物学家之间早先的争论不谋而合。这些争论包括非达尔文机制的作用、中性进化的贡献以及生命史动态。增殖与转移之间的权衡是生命史理论在癌症进化中最深入的应用。本文简要介绍了癌症与物种进化之间的一些相似之处，重点关注不断进化的肿瘤的生命史。接下来，我们回顾了模拟和实验研究中支持癌症中任务专业化和权衡的证据。我们还介绍了从数据中推断肿瘤任务的最新研究成果。然后，我们将讨论多任务的意义以及该理论在解释肿瘤异质性关键方面的实用性。最后，我们将讨论这一研究课题的一些批评意见和未来发展方向。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Cell International ONCOLOGY-

CiteScore

10.90

自引率

1.70%

发文量

360

审稿时长

1 months

期刊介绍： Cancer Cell International publishes articles on all aspects of cancer cell biology, originating largely from, but not limited to, work using cell culture techniques. The journal focuses on novel cancer studies reporting data from biological experiments performed on cells grown in vitro, in two- or three-dimensional systems, and/or in vivo (animal experiments). These types of experiments have provided crucial data in many fields, from cell proliferation and transformation, to epithelial-mesenchymal interaction, to apoptosis, and host immune response to tumors. Cancer Cell International also considers articles that focus on novel technologies or novel pathways in molecular analysis and on epidemiological studies that may affect patient care, as well as articles reporting translational cancer research studies where in vitro discoveries are bridged to the clinic. As such, the journal is interested in laboratory and animal studies reporting on novel biomarkers of tumor progression and response to therapy and on their applicability to human cancers.