Association of triglyceride-glucose index and its combination with obesity indicators in predicting the risk of aortic aneurysm and dissection.

IF 4 2区农林科学 Q2 NUTRITION & DIETETICS Frontiers in Nutrition Pub Date : 2024-10-23 eCollection Date: 2024-01-01 DOI:10.3389/fnut.2024.1454880

Wangqin Yu, Xiaoling Wang, Zhongyan Du, Wenke Cheng

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Abstract

Background: The association between the triglyceride-glucose (TyG) index and its combination with obesity indictors in aortic aneurysm and dissection (AAD) remains unclear. We aimed to investigate the association between TyG and TyG-body mass index (TyG-BMI), TyG-waist circumference (TyG-WC), TyG-waist height ratio (TyG-WHtR) and AAD risk.

Methods: This study included 387,483 baseline participants from the UK Biobank with complete data on TyG, TyG-BMI, TyG-WC and TyG-WHtR. Cox proportional hazard models evaluated the relationship between these four indicators and the risk of AAD occurrence. Restricted cubic spline (RCS) examined the non-linear relationship between these indicators and AAD risk, while receiver operating characteristic (ROC) curves assessed the predictive value of these four indicators for AAD risk.

Results: Over a median follow-up of 13.7 years, 3,041 AAD events were recorded. Multivariate Cox regression analysis indicated that for each standard deviation increase, the risk of AAD occurrence increased by 33% (HR: 1.33, 95%CI: 1.29-1.38), 25% (HR: 1.25, 95%CI: 1.21-1.29), 61% (HR: 1.61, 95%CI: 1.56-1.66) and 44% (HR: 1.44, 95%CI: 1.39-1.49) for TyG, TyG-BMI, TyG-WC and TyG-WHtR, respectively. RCS demonstrated a linear relationship between these indicators and AAD risk, with TyG-WC demonstrating the best performance in predicting AAD occurrence based on ROC curves.

Conclusion: The present study, based on a large prospective cohort design, showed that higher TyG index and its combination with obesity indices were significantly associated with the risk of AAD. Moreover, AFT models further showed that elevation of these indicators significantly advanced the onset of AAD. In addition, RCS analyses demonstrated a linear association between these indicators and the risk of AAD, and the TyG-WC showed higher predictive ability for AAD. These findings emphasize the potential application of the TyG index and its combination with obesity indicators in the early identification of AAD.

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甘油三酯-葡萄糖指数及其与肥胖指标的结合在预测主动脉瘤和夹层风险方面的关联。

背景：主动脉瘤和夹层（AAD）中甘油三酯-葡萄糖（TyG）指数及其与肥胖指标的组合之间的关系仍不清楚。我们旨在研究 TyG 与 TyG-体重指数（TyG-BMI）、TyG-腰围（TyG-WC）、TyG-腰高比（TyG-WHtR）和 AAD 风险之间的关系：该研究纳入了英国生物库（UK Biobank）中的387,483名基线参与者，这些参与者拥有完整的TyG、TyG-BMI、TyG-WC和TyG-WHtR数据。Cox 比例危险模型评估了这四个指标与 AAD 发生风险之间的关系。限制立方样条曲线（RCS）检验了这些指标与AAD风险之间的非线性关系，而接收者操作特征曲线（ROC）评估了这四个指标对AAD风险的预测价值：在中位 13.7 年的随访期间，共记录了 3,041 起急性心力衰竭事件。多变量 Cox 回归分析表明，TyG、TyG-BMI、TyG-WC 和 TyG-WHtR 每增加一个标准差，AAD 发生风险分别增加 33%（HR：1.33，95%CI：1.29-1.38）、25%（HR：1.25，95%CI：1.21-1.29）、61%（HR：1.61，95%CI：1.56-1.66）和 44%（HR：1.44，95%CI：1.39-1.49）。RCS显示这些指标与AAD风险之间存在线性关系，根据ROC曲线，TyG-WC在预测AAD发生率方面表现最佳：本研究基于大型前瞻性队列设计，显示较高的 TyG 指数及其与肥胖指数的组合与 AAD 风险显著相关。此外，AFT 模型还进一步表明，这些指标的升高会大大提前急性心力衰竭的发病时间。此外，RCS 分析表明这些指标与 AAD 风险之间存在线性关系，TyG-WC 对 AAD 的预测能力更高。这些发现强调了TyG指数及其与肥胖指标的结合在早期识别AAD中的潜在应用。

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来源期刊

Frontiers in Nutrition Agricultural and Biological Sciences-Food Science

CiteScore

5.20

自引率

8.00%

发文量

2891

审稿时长

12 weeks

期刊介绍： No subject pertains more to human life than nutrition. The aim of Frontiers in Nutrition is to integrate major scientific disciplines in this vast field in order to address the most relevant and pertinent questions and developments. Our ambition is to create an integrated podium based on original research, clinical trials, and contemporary reviews to build a reputable knowledge forum in the domains of human health, dietary behaviors, agronomy & 21st century food science. Through the recognized open-access Frontiers platform we welcome manuscripts to our dedicated sections relating to different areas in the field of nutrition with a focus on human health. Specialty sections in Frontiers in Nutrition include, for example, Clinical Nutrition, Nutrition & Sustainable Diets, Nutrition and Food Science Technology, Nutrition Methodology, Sport & Exercise Nutrition, Food Chemistry, and Nutritional Immunology. Based on the publication of rigorous scientific research, we thrive to achieve a visible impact on the global nutrition agenda addressing the grand challenges of our time, including obesity, malnutrition, hunger, food waste, sustainability and consumer health.