Iron deficiency in dogs suffering from atopic dermatitis.

IF 2.3 2区 农林科学 Q1 VETERINARY SCIENCES BMC Veterinary Research Pub Date : 2024-11-06 DOI:10.1186/s12917-024-04350-y
Carolina Frizzo Ramos, Pavlos G Doulidis, Nina Polakova, Iwan A Burgener, Erika Jensen-Jarolim, Giulia Cimarelli, Lucia Panakova, Franziska Roth-Walter
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Abstract

Background: Iron-deficiency is associated with increased morbidity and mortality in non-communicable diseases. However, iron parameters are rarely assessed in dogs. Here, we aimed to assess and correlate iron parameters in dogs suffering from Canine Atopic Dermatitis (CAD) compared to non-atopic, healthy dogs.

Results: For this retrospective study, blood values and sera of 34 dogs with confirmed CAD were compared with 94 healthy non-atopic dogs. In our cohort, dogs with CAD had significantly lower mean corpuscular volume (MCV, ) mean corpuscular hemoglobin (MCH) but higher white blood cell counts due to increased levels of circulating neutrophils and monocytes. CAD patients also had elevated total protein and c-reactive protein (CRP), but lower albumin levels compared to our healthy control dogs, indicated low-grade inflammation in the CAD cohort. Spearman correlations associated negatively clinical symptom (CADESI-4/PVAS) with MCV; ceruloplasmin and hepcidin, but positively with serum iron. Only in the CAD-cohort, MCV, CRP and albumin-levels negatively affected serum iron-levels and were positively associated with ceruloplasmin. Linear regression analysis revealed that serum iron-levels in CAD subjects, were positively dependent on hematocrit (packed cell volume, PCV) and albumin, and negatively dependent with white blood cells and neutrophils numbers. In contrast, in the healthy cohort, hepcidin was the sole factor associated with serum iron.

Conclusions: A decreased iron status was associated with a higher symptom burden. Iron homeostasis differed markedly in healthy and atopic dermatitis dogs. CAD patients had depleted iron-stores and presented themselves with subclinical inflammation.

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患有特应性皮炎的狗缺铁。
背景:缺铁与非传染性疾病的发病率和死亡率增加有关。然而,很少对犬的铁参数进行评估。在此,我们旨在评估犬异位性皮炎(CAD)患者与非异位性皮炎健康犬的铁参数并进行相关比较:在这项回顾性研究中,我们将 34 只确诊为犬特应性皮炎的犬的血液值和血清与 94 只非特应性皮炎的健康犬进行了比较。在我们的队列中,患有 CAD 的狗的平均血球容积(MCV)和平均血球血红蛋白(MCH)明显较低,但由于循环中性粒细胞和单核细胞水平升高,白细胞计数较高。与健康对照犬相比,CAD 患者的总蛋白和 c 反应蛋白 (CRP) 也有所升高,但白蛋白水平较低,这表明 CAD 组群中存在低度炎症。临床症状(CADESI-4/PVAS)与 MCV、ceruloplasmin 和 hepcidin 呈负相关,但与血清铁呈正相关。只有在 CAD 队列中,MCV、CRP 和白蛋白水平对血清铁水平呈负相关,而与脑磷脂蛋白呈正相关。线性回归分析表明,在 CAD 受试者中,血清铁水平与血细胞比容(包装细胞体积,PCV)和白蛋白呈正相关,而与白细胞和中性粒细胞数量呈负相关。相比之下,在健康人群中,血红素是唯一与血清铁相关的因素:结论:铁含量降低与症状加重有关。健康犬和特应性皮炎犬体内的铁平衡存在明显差异。特应性皮炎患者体内的铁储存耗尽,并表现出亚临床炎症。
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来源期刊
BMC Veterinary Research
BMC Veterinary Research VETERINARY SCIENCES-
CiteScore
4.80
自引率
3.80%
发文量
420
审稿时长
3-6 weeks
期刊介绍: BMC Veterinary Research is an open access, peer-reviewed journal that considers articles on all aspects of veterinary science and medicine, including the epidemiology, diagnosis, prevention and treatment of medical conditions of domestic, companion, farm and wild animals, as well as the biomedical processes that underlie their health.
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