Association of maternal 25(OH)D levels during pregnancy with fetal birth weight and preschooler growth status: A retrospective birth cohort study.

IF 1.6 4区 医学 Q3 OBSTETRICS & GYNECOLOGY Journal of Obstetrics and Gynaecology Research Pub Date : 2024-11-06 DOI:10.1111/jog.16143
Lan Yang, Zhengjia Ling, Di Yao, Jingna Su, Shufeng He, Xiaopei Zhou, Ying Gu
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Abstract

Aim: There is limited and conflicting evidence available regarding the correlation between maternal vitamin D status and childhood overweight and body mass index (BMI). The aim of this study was to investigate the following: (1) potential association between maternal 25-hydroxyvitamin D (25(OH)D) levels and newborn growth status; (2) relationship between maternal 25OHD levels and BMI and the risk of overweight with preschoolers being overweight.

Methods: A cohort of 3213 eligible singleton mother-infant pairs were used to investigate the possible associations between maternal 25(OH)D levels and fetal growth status. Data of 1767 available singleton mother-infant pairs and 6-year-old preschoolers was applied to analyze the potential correlations between maternal 25(OH)D status and risk of childhood overweight.

Results: Compared with sufficient 25(OH)D in pregnancy group (≥75 nmol/L), there were no correlations between the maternal 25(OH)D deficiency (<50 nmol/L) and large gestational age (LGA) (p = 0.465), small gestational age (SGA) (p = 0.607), lower birth weight (LBW) (p = 0.725) or fetal macrosomia (p = 0.535). Moreover, no significant associations between insufficient maternal 25(OH)D (50-75 nmol/L) and LGA (p = 0.505), SGA (p = 0.816), LBW (p = 0.816), or fetal macrosomia (p = 0.413) were observed. We found statistically significant disparities between the fetal birth weight and height (p < 0.001), weight (p < 0.001), head circumference (p = 0.001) of 6-years preschooler. No significant associations were found between the maternal 25(OH)D levels and BMI and risk of overweight at 6-year-old preschoolers.

Conclusion: There were no apparent correlation found between maternal 25(OH)D concentrations and fetal birth status. There was no evidence found to suggest the effect of maternal 25(OH)D level on overweight at 6-year-old preschoolers.

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孕期母体 25(OH)D 水平与胎儿出生体重和学龄前儿童生长状况的关系:一项回顾性出生队列研究。
目的:关于母体维生素 D 状态与儿童超重和体重指数(BMI)之间的相关性,现有证据有限且相互矛盾。本研究旨在调查以下内容:(1) 母体 25- 羟基维生素 D(25(OH)D)水平与新生儿生长状况之间的潜在关联;(2) 母体 25OHD 水平与 BMI 之间的关系以及学龄前儿童超重的风险:方法:研究人员对 3213 对符合条件的单胎母婴进行了队列研究,以探讨母体 25(OH)D 水平与胎儿生长状况之间可能存在的关联。应用1767对符合条件的单胎母婴和6岁学龄前儿童的数据,分析了母亲25(OH)D水平与儿童超重风险之间的潜在相关性:结果:与孕期25(OH)D充足组(≥75 nmol/L)相比,母体25(OH)D缺乏与儿童超重风险之间没有相关性:母体 25(OH)D 浓度与胎儿出生状况之间没有明显的相关性。没有证据表明母体 25(OH)D 水平对 6 岁学龄前儿童超重有影响。
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来源期刊
CiteScore
3.10
自引率
0.00%
发文量
376
审稿时长
3-6 weeks
期刊介绍: The Journal of Obstetrics and Gynaecology Research is the official Journal of the Asia and Oceania Federation of Obstetrics and Gynecology and of the Japan Society of Obstetrics and Gynecology, and aims to provide a medium for the publication of articles in the fields of obstetrics and gynecology. The Journal publishes original research articles, case reports, review articles and letters to the editor. The Journal will give publication priority to original research articles over case reports. Accepted papers become the exclusive licence of the Journal. Manuscripts are peer reviewed by at least two referees and/or Associate Editors expert in the field of the submitted paper.
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