Systematic characterization of new EBT4 radiochromic films in clinical x-ray beams.

IF 1.3 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Biomedical Physics & Engineering Express Pub Date : 2024-11-06 DOI:10.1088/2057-1976/ad8c49
Rao Khan, Robabeh Rahimi, Jiajin Fan, Kuan Ling Chen
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Abstract

Objective. We aim to characterize kinetics of radiation-induced optical density in newly released EBT4 radiochromic films exposed to clinical x-rays. Several film models and batches were evaluated for the film sensitivity, optical signal increasing with time, relative film noise, and minimum detectable limits (MDL).Approach. Radiochromic film pieces from a single batch of EBT3 and three batches of EBT4 were exposed to doses of 77.38 cGy, 386.92 cGy, and 773.84 cGy using a 6 MV x-ray beam. The films were scanned with a flatbed scanner at specific time intervals up to 120 h. The time-series net optical density of red, green and blue colors was corrected for response of the scanner with time and studied to establish the saturation characteristics of film polymerization process. Dose-response from 3.86 cGy to 1935 cGy was also determined for each color. MDL of the films was quantitatively defined as the dose that would double the net optical density of red color above the standard deviation of the residual signal at zero dose. The relative noise characteristics of EBT3 versus EBT4 were studied as a function of time, dose and scanner resolution.Main Results. For doses ≥ 100 cGy, analysis revealed a stability of optical density beyond 48 h post-exposure for EBT3 and EBT4 films. EBT3 films attained 80%-90% of their net optical density at 48 h within minutes of irradiation, compared to 72%-88% for EBT4 films. The rate of growth was slowest for blue color, fastest for red, while green was in between the two. The MDL for EBT4 averaged 15 cGy for three batches, whereas EBT3 films reliably detected doses as low as 8.5 cGy.Significance. Several batches of the new EBT4 film showed slightly lower response compared to its predecessor over 3.86 cGy to 1935 Gy range. For all practical purposes, the post-irradiation growth of polymers ceases between 48 to 60 h for both EBT films. Overall, the EBT4 film exhibited noise characteristics similar to EBT3, except for lower doses where the noise was observed to be higher than its predecessor.

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在临床 X 射线束中对新型 EBT4 射线变色薄膜进行系统鉴定。
研究目的我们的目的是描述新发布的 EBT4 射线变色胶片在临床 X 射线照射下的辐射诱导光密度动力学。我们对几种型号和几批胶片的灵敏度、随时间增加的光学信号、相对胶片噪声和最低检测限(MDL)进行了评估。使用 6 MV X 射线束将单批 EBT3 和三批 EBT4 的放射性变色胶片分别照射 77.38 cGy、386.92 cGy 和 773.84 cGy 的剂量。用平板扫描仪按特定的时间间隔对薄膜进行扫描,扫描时间最长可达 120 小时。红、绿、蓝三色的时间序列净光学密度根据扫描仪随时间变化的响应进行校正,并对其进行研究,以确定薄膜聚合过程的饱和特性。还测定了每种颜色从 3.86 cGy 到 1935 cGy 的剂量反应。薄膜的 MDL 被定量定义为使红色的净光密度比零剂量时残留信号的标准偏差高出一倍的剂量。作为时间、剂量和扫描仪分辨率的函数,研究了 EBT3 与 EBT4 的相对噪声特性。对于剂量≥ 100 cGy 的情况,分析表明 EBT3 和 EBT4 胶片在曝光后 48 小时内光密度保持稳定。EBT3 薄膜在辐照后几分钟内就达到了 48 小时净光密度的 80%-90% ,而 EBT4 薄膜则为 72%-88% 。蓝色的增长速度最慢,红色的增长速度最快,而绿色则介于两者之间。三批 EBT4 的 MDL 平均为 15 cGy,而 EBT3 薄膜能可靠地检测到低至 8.5 cGy 的剂量。在 3.86 cGy 到 1935 Gy 的范围内,几批新的 EBT4 薄膜的反应比其前身略低。实际上,两种 EBT 薄膜的聚合物辐照后生长都在 48 到 60 小时之间停止。总体而言,EBT4 薄膜的噪声特性与 EBT3 相似,只是在低剂量时噪声高于前者。
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来源期刊
Biomedical Physics & Engineering Express
Biomedical Physics & Engineering Express RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-
CiteScore
2.80
自引率
0.00%
发文量
153
期刊介绍: BPEX is an inclusive, international, multidisciplinary journal devoted to publishing new research on any application of physics and/or engineering in medicine and/or biology. Characterized by a broad geographical coverage and a fast-track peer-review process, relevant topics include all aspects of biophysics, medical physics and biomedical engineering. Papers that are almost entirely clinical or biological in their focus are not suitable. The journal has an emphasis on publishing interdisciplinary work and bringing research fields together, encompassing experimental, theoretical and computational work.
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