A Prospective Analysis of Per- and Polyfluoroalkyl Substances from Early Pregnancy to Delivery in the Atlanta African American Maternal-Child Cohort.

IF 10.1 1区 环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES Environmental Health Perspectives Pub Date : 2024-11-01 Epub Date: 2024-11-06 DOI:10.1289/EHP14334
Youran Tan, Stephanie M Eick, Anne L Dunlop, Dana Boyd Barr, Kaitlin R Taibl, Kyle Steenland, Kurunthachalam Kannan, Morgan Robinson, Che-Jung Chang, Parinya Panuwet, Volha Yakimavets, Carmen J Marsit, P Barry Ryan, Donghai Liang
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Abstract

Background: Longitudinal trends in per- and polyfluoroalkyl substances (PFAS) serum concentrations across pregnancy have not been thoroughly examined, despite evidence linking prenatal PFAS exposures with adverse birth outcomes.

Objectives: We sought to characterize longitudinal PFAS concentrations across pregnancy and to examine the maternal-fetal transfer ratio among participants in a study of risk and protective factors for adverse birth outcomes among African Americans.

Methods: In the Atlanta African American Maternal-Child cohort (2014-2020), we quantified serum concentrations of four PFAS in 376 participants and an additional eight PFAS in a subset of 301 participants during early (8-14 weeks gestation) and late pregnancy (24-30 weeks gestation). Among these, PFAS concentrations were also measured among 199 newborns with available dried blood spot (DBS) samples. We characterized the patterns, variability, and associations in PFAS concentrations at different time points across pregnancy using intraclass correlation coefficients (ICCs), maternal-newborn pairs transfer ratios, linear mixed effect models, and multivariable linear regression, adjusting for socioeconomic and prenatal predictors.

Results: Perfluorohexane sulfonic acid (PFHxS), perfluorooctane sulfonic acid (PFOS), perfluorooctanoic acid (PFOA), and perfluorononanoic acid (PFNA) were detected in >95% of maternal samples, with PFHxS and PFOS having the highest median concentrations. We observed high variability in PFAS concentrations across pregnancy time points (ICC=0.03-0.59). All median PFAS concentrations increased from early to late pregnancy, except for PFOA and N-methyl perfluorooctane sulfonamido acetic acid (NMFOSAA), which decreased [paired t-test for all PFAS p<0.05 except for PFOA and perfluorobutane sulfonic acid (PFBS)]. Prenatal serum PFAS were weakly to moderately correlated with newborn DBS PFAS (-0.05<rho <0.49). The median maternal-fetal PFAS transfer ratio was lower for PFAS with longer carbon chains. After adjusting for socioeconomic and prenatal predictors, in linear mixed effect models, the adjusted mean PFAS concentrations significantly increased during pregnancy, except for PFOA. In multivariable linear regression, PFAS concentrations in early pregnancy significantly predicted the PFAS concentrations in late pregnancy and in newborns.

Discussion: We found that the concentrations of most PFAS increased during pregnancy, and the magnitude of variability differed by individual PFAS. Future studies are needed to understand the influence of within-person PFAS variability during and after pregnancy on birth outcomes. https://doi.org/10.1289/EHP14334.

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亚特兰大非裔美国人母婴队列中从怀孕早期到分娩的全氟和多氟烷基物质前瞻性分析。
背景:尽管有证据表明产前全氟烷基和多氟烷基物质(PFAS)暴露与不良出生结局有关,但对整个孕期全氟烷基和多氟烷基物质(PFAS)血清浓度的纵向趋势尚未进行深入研究:我们试图描述妊娠期间纵向 PFAS 浓度的特征,并检查非裔美国人不良出生结果风险和保护因素研究参与者的母胎转移比:在亚特兰大非裔美国人母婴队列(2014-2020 年)中,我们量化了 376 名参与者血清中四种 PFAS 的浓度,以及 301 名参与者在孕早期(妊娠 8-14 周)和孕晚期(妊娠 24-30 周)血清中另外八种 PFAS 的浓度。其中,我们还测量了 199 名新生儿干血斑 (DBS) 样本中的 PFAS 浓度。我们使用类内相关系数 (ICC)、母体-新生儿对转移比、线性混合效应模型和多变量线性回归,对社会经济因素和产前预测因素进行了调整,从而确定了整个孕期不同时间点的全氟辛烷磺酸浓度的模式、变异性和关联性:95%以上的母体样本中都检测到了全氟己烷磺酸(PFHxS)、全氟辛烷磺酸(PFOS)、全氟辛酸(PFOA)和全氟壬酸(PFNA),其中全氟己烷磺酸和全氟辛烷磺酸的中位浓度最高。我们观察到,不同妊娠时间点的 PFAS 浓度差异很大(ICC=0.03-0.59)。除了 PFOA 和 N-甲基全氟辛烷磺酰胺乙酸(NMFOSAA)的中位数浓度有所下降外,所有 PFAS 的中位数浓度从孕早期到孕晚期均有所上升[除了 PFOA 和全氟丁烷磺酸(PFBS)外,所有 PFAS 的配对 t 检验结果均为 p0.05]。产前血清中的 PFAS 与新生儿 DBS 中的 PFAS 呈弱至中度相关(-0.05rho 0.49)。碳链较长的 PFAS 的母胎 PFAS 转移比中位数较低。在线性混合效应模型中,调整社会经济因素和产前预测因素后,调整后的 PFAS 平均浓度在孕期显著增加,但 PFOA 除外。在多变量线性回归中,孕早期的 PFAS 浓度可显著预测孕晚期和新生儿的 PFAS 浓度:讨论:我们发现,大多数 PFAS 的浓度在孕期都会增加,而且不同 PFAS 的变化幅度也不同。未来的研究需要了解妊娠期间和妊娠后人体内 PFAS 变异对出生结果的影响。https://doi.org/10.1289/EHP14334。
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来源期刊
Environmental Health Perspectives
Environmental Health Perspectives 环境科学-公共卫生、环境卫生与职业卫生
CiteScore
14.40
自引率
2.90%
发文量
388
审稿时长
6 months
期刊介绍: Environmental Health Perspectives (EHP) is a monthly peer-reviewed journal supported by the National Institute of Environmental Health Sciences, part of the National Institutes of Health under the U.S. Department of Health and Human Services. Its mission is to facilitate discussions on the connections between the environment and human health by publishing top-notch research and news. EHP ranks third in Public, Environmental, and Occupational Health, fourth in Toxicology, and fifth in Environmental Sciences.
期刊最新文献
Gut Check: Microbiota and Obesity in Mice Exposed to Polystyrene Microspheres. A Prospective Analysis of Per- and Polyfluoroalkyl Substances from Early Pregnancy to Delivery in the Atlanta African American Maternal-Child Cohort. A Bigger Big Picture: Insights on Environmental Chemicals and Dyslipidemia through Combined "Omic" Analyses. Cancer Incidence among Marines and Navy Personnel and Civilian Workers Exposed to Industrial Solvents in Drinking Water at US Marine Corps Base Camp Lejeune: A Cohort Study. Invited Perspective: Insights into Exposure to Industrial Solvents and Cancer Risk at Camp Lejeune.
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