<p><strong>Background: </strong>Transboundary PM<sub>2.5</sub> pollution is causing significant environmental conflicts among China, South Korea, and Japan. However, efforts to address these conflicts have been impeded by a lack of a comprehensive understanding of source-receptor relationships of PM<sub>2.5</sub> pollution and associated health impacts among these countries.</p><p><strong>Objectives: </strong>We quantify the extent to which transboundary PM<sub>2.5</sub> pollution and associated health impacts are mutual among the three countries in 2015 and 2017 using three metrics (population-weighted mean PM<sub>2.5</sub> concentration, PM<sub>2.5</sub> population exposure, and PM<sub>2.5</sub>-related premature deaths) and two accounting perspectives (production and consumption).</p><p><strong>Methods: </strong>We adopt an integrated interdisciplinary analysis framework that links an environmentally-extended multi-regional input-output model, a GEOS-Chem chemical transport model, a population exposure model, and an exposure-response model.</p><p><strong>Results: </strong>From a production perspective, China's contributions to population-weighted mean PM<sub>2.5</sub> concentrations in South Korea and Japan are considerable, while the contributions of South Korea and Japan to China are negligible. However, the contributions from South Korea and Japan to PM<sub>2.5</sub> population exposure and associated premature deaths in China are nonnegligible from both production and consumption perspectives. From a consumption perspective, the contributions of South Korea and Japan to PM<sub>2.5</sub>-related premature deaths in China amount to 6.96 [95% confidence interval (CI): 6.36, 7.56] and 9.79 (95% CI: 8.93, 10.64) thousand deaths in 2015, respectively, and 5.03 (95% CI: 4.55, 5.49) and 7.75 (95% CI: 7.02, 8.47) in 2017, respectively. These figures are generally larger than China's contributions to PM<sub>2.5</sub>-related premature deaths in South Korea and Japan, which measure 4.63 (95% CI: 3.97, 5.28) and 3.91 (95% CI: 2.78, 5.01) thousand deaths in 2015, respectively, and 4.43 (95% CI: 3.75, 5.1) and 3.69 (95% CI: 2.57, 4.79) in 2017, respectively.</p><p><strong>Discussion: </strong>Our findings show that mutual contributions of PM<sub>2.5</sub> pollution and associated health impacts among the three countries vary considerably when different metrics and accounting perspectives are applied. A consumption perspective reveals narrower gaps in mutual contributions than a production perspective. Moreover, other countries outside Northeast Asia may have played a significant role in contributing to PM<sub>2.5</sub> pollution and associated health impacts in Northeast Asia, suggesting that Northeast Asian countries should look beyond this region and collaborate with the rest of the world to jointly develop effective PM<sub>2.5</sub> mitigation strategies. Our findings could help policy makers, scholars, and the public in China, South Korea, and Japan
{"title":"Quantifying the source-receptor relationships of PM<sub>2.5</sub> pollution and associated health impacts among China, South Korea, and Japan: A dual perspective and an interdisciplinary approach.","authors":"Jianzheng Liu, Fei Yao, Hongwen Chen, Hongyan Zhao","doi":"10.1289/EHP14550","DOIUrl":"https://doi.org/10.1289/EHP14550","url":null,"abstract":"<p><strong>Background: </strong>Transboundary PM<sub>2.5</sub> pollution is causing significant environmental conflicts among China, South Korea, and Japan. However, efforts to address these conflicts have been impeded by a lack of a comprehensive understanding of source-receptor relationships of PM<sub>2.5</sub> pollution and associated health impacts among these countries.</p><p><strong>Objectives: </strong>We quantify the extent to which transboundary PM<sub>2.5</sub> pollution and associated health impacts are mutual among the three countries in 2015 and 2017 using three metrics (population-weighted mean PM<sub>2.5</sub> concentration, PM<sub>2.5</sub> population exposure, and PM<sub>2.5</sub>-related premature deaths) and two accounting perspectives (production and consumption).</p><p><strong>Methods: </strong>We adopt an integrated interdisciplinary analysis framework that links an environmentally-extended multi-regional input-output model, a GEOS-Chem chemical transport model, a population exposure model, and an exposure-response model.</p><p><strong>Results: </strong>From a production perspective, China's contributions to population-weighted mean PM<sub>2.5</sub> concentrations in South Korea and Japan are considerable, while the contributions of South Korea and Japan to China are negligible. However, the contributions from South Korea and Japan to PM<sub>2.5</sub> population exposure and associated premature deaths in China are nonnegligible from both production and consumption perspectives. From a consumption perspective, the contributions of South Korea and Japan to PM<sub>2.5</sub>-related premature deaths in China amount to 6.96 [95% confidence interval (CI): 6.36, 7.56] and 9.79 (95% CI: 8.93, 10.64) thousand deaths in 2015, respectively, and 5.03 (95% CI: 4.55, 5.49) and 7.75 (95% CI: 7.02, 8.47) in 2017, respectively. These figures are generally larger than China's contributions to PM<sub>2.5</sub>-related premature deaths in South Korea and Japan, which measure 4.63 (95% CI: 3.97, 5.28) and 3.91 (95% CI: 2.78, 5.01) thousand deaths in 2015, respectively, and 4.43 (95% CI: 3.75, 5.1) and 3.69 (95% CI: 2.57, 4.79) in 2017, respectively.</p><p><strong>Discussion: </strong>Our findings show that mutual contributions of PM<sub>2.5</sub> pollution and associated health impacts among the three countries vary considerably when different metrics and accounting perspectives are applied. A consumption perspective reveals narrower gaps in mutual contributions than a production perspective. Moreover, other countries outside Northeast Asia may have played a significant role in contributing to PM<sub>2.5</sub> pollution and associated health impacts in Northeast Asia, suggesting that Northeast Asian countries should look beyond this region and collaborate with the rest of the world to jointly develop effective PM<sub>2.5</sub> mitigation strategies. Our findings could help policy makers, scholars, and the public in China, South Korea, and Japan","PeriodicalId":11862,"journal":{"name":"Environmental Health Perspectives","volume":" ","pages":""},"PeriodicalIF":10.1,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ariell B Stephens, Albert B Rivera, Thomas M Cahill, Maxwell C K Leung
{"title":"Evaluation of <i>Fusarium</i> Mycotoxins and Fungal Metabolites in Seized Cannabis in Arizona and California, 2023-2024.","authors":"Ariell B Stephens, Albert B Rivera, Thomas M Cahill, Maxwell C K Leung","doi":"10.1289/EHP16028","DOIUrl":"https://doi.org/10.1289/EHP16028","url":null,"abstract":"","PeriodicalId":11862,"journal":{"name":"Environmental Health Perspectives","volume":" ","pages":""},"PeriodicalIF":10.1,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comment on \"Exposure to Per- and Polyfluoroalkyl Substances and Mortality in U.S. Adults: A Population-Based Cohort Study\".","authors":"Tony Fletcher","doi":"10.1289/EHP17149","DOIUrl":"https://doi.org/10.1289/EHP17149","url":null,"abstract":"","PeriodicalId":11862,"journal":{"name":"Environmental Health Perspectives","volume":" ","pages":""},"PeriodicalIF":10.1,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143630247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Erich Batzella, Isabella Rosato, Gisella Pitter, Filippo Da Re, Francesca Russo, Cristina Canova, Tony Fletcher
{"title":"Erratum: \"Determinants of PFOA serum half-life after end of exposure: a longitudinal study on highly exposed subjects in the Veneto Region\".","authors":"Erich Batzella, Isabella Rosato, Gisella Pitter, Filippo Da Re, Francesca Russo, Cristina Canova, Tony Fletcher","doi":"10.1289/EHP17398","DOIUrl":"https://doi.org/10.1289/EHP17398","url":null,"abstract":"","PeriodicalId":11862,"journal":{"name":"Environmental Health Perspectives","volume":" ","pages":""},"PeriodicalIF":10.1,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143630248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Response to \"Comment on 'Exposure to Per- and Polyfluoroalkyl Substances and Mortality in U.S. Adults: A Population-Based Cohort Study'\".","authors":"Xue Wen, Mei Wang, Xuewen Xu, Tao Li","doi":"10.1289/EHP17324","DOIUrl":"https://doi.org/10.1289/EHP17324","url":null,"abstract":"","PeriodicalId":11862,"journal":{"name":"Environmental Health Perspectives","volume":" ","pages":""},"PeriodicalIF":10.1,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143630251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Wenxin Wan, Susan Peters, Lützen Portengen, Ronnie Babigumira, Jo Steinson Stenehjem, David Richardson, Roel Vermeulen
{"title":"Response to \"Comment on 'Occupational Benzene Exposure and Lung Cancer in Human Studies: A Systematic Review and Meta-Analysis'\".","authors":"Wenxin Wan, Susan Peters, Lützen Portengen, Ronnie Babigumira, Jo Steinson Stenehjem, David Richardson, Roel Vermeulen","doi":"10.1289/EHP17293","DOIUrl":"https://doi.org/10.1289/EHP17293","url":null,"abstract":"","PeriodicalId":11862,"journal":{"name":"Environmental Health Perspectives","volume":" ","pages":""},"PeriodicalIF":10.1,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143623952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comment on \"Occupational Benzene Exposure and Lung Cancer in Human Studies: A Systematic Review and Meta-Analysis\".","authors":"Jian Huang","doi":"10.1289/EHP17036","DOIUrl":"https://doi.org/10.1289/EHP17036","url":null,"abstract":"","PeriodicalId":11862,"journal":{"name":"Environmental Health Perspectives","volume":" ","pages":""},"PeriodicalIF":10.1,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143623950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comment on \"Asking Why Is Necessary to Address Health Disparities: A Critical Approach for Solution-Oriented Environmental Epidemiological Research\".","authors":"Alvaro J Idrovo","doi":"10.1289/EHP16851","DOIUrl":"https://doi.org/10.1289/EHP16851","url":null,"abstract":"","PeriodicalId":11862,"journal":{"name":"Environmental Health Perspectives","volume":" ","pages":""},"PeriodicalIF":10.1,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143613970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Eliseo F Castillo, Katrina Smith Korfmacher, Anna Christina Tyler
{"title":"Invited Perspective: Should You Scrap Your Plastic Cutting Board?","authors":"Eliseo F Castillo, Katrina Smith Korfmacher, Anna Christina Tyler","doi":"10.1289/EHP17049","DOIUrl":"https://doi.org/10.1289/EHP17049","url":null,"abstract":"","PeriodicalId":11862,"journal":{"name":"Environmental Health Perspectives","volume":" ","pages":""},"PeriodicalIF":10.1,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143585155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ruth Geller, Amelia K Wesselink, Birgit Claus Henn, Kristen Upson, Marco Vinceti, Quaker E Harmon, Donna D Baird, Ganesa Wegienka, Lauren A Wise
Background: Uterine leiomyomata (UL), hormone-dependent neoplasms, are a major source of gynecologic morbidity. Metals are hypothesized to influence UL risk through endocrine disruption, and their effects may vary by vitamin D status.
Objective: We estimated associations of a metal mixture with incident UL, overall and by vitamin D status.
Methods: We analyzed data from the Study of Environment, Lifestyle and Fibroids, a Detroit-area prospective cohort study of 1,693 Black women aged 23-35 years. We measured concentrations of 17 metals/metalloids in whole blood and 25-hydroxyvitamin D (25[OH]D) in serum collected at baseline (2010-2012). Participants underwent ultrasonography at baseline and after 20 months to detect UL. We used Bayesian Kernel Machine Regression to estimate adjusted associations (β) of the metal mixture with probit of incident UL. We also ran Cox regression models with interaction terms to estimate incidence rate ratios (IRR) by vitamin D status.
Results: Among 1,132 UL-free participants at baseline, 832 (73%) had vitamin D deficiency (25[OH]D<20 ng/mL) and 117 (10%) developed UL within 20 months. Increasing all metals from their 50th to 75th percentiles was weakly positively associated with UL overall (β=0.06, 95% credible interval [CrI]: -0.03, 0.16) and among vitamin D-deficient participants (β=0.13, 95% CrI: 0.01, 0.24), driven by cadmium (overall and vitamin D-deficient) and mercury (vitamin D-deficient only). Increasing cadmium from its 25th to 75th percentile was positively associated with UL overall (β=0.03, 95% CrI: -0.05, 0.11) and among vitamin D-deficient participants (β=0.13, 95% CrI: 0.02, 0.24). In Cox models, cadmium (IRR=1.55, 95% confidence interval [CI]: 1.07, 2.24, per 1-unit increase in standardized concentration) and mercury (IRR=1.38, 95% CI: 0.99, 1.92) were positively associated with UL among vitamin D-deficient participants.
Discussion: The metal mixture was positively associated with incident UL, but the association was weak and imprecise. We observed a stronger association among vitamin D-deficient participants that was driven by cadmium and mercury. https://doi.org/10.1289/EHP15218.
{"title":"A prospective ultrasound study of whole blood metals and incidence of uterine leiomyomata.","authors":"Ruth Geller, Amelia K Wesselink, Birgit Claus Henn, Kristen Upson, Marco Vinceti, Quaker E Harmon, Donna D Baird, Ganesa Wegienka, Lauren A Wise","doi":"10.1289/EHP15218","DOIUrl":"https://doi.org/10.1289/EHP15218","url":null,"abstract":"<p><strong>Background: </strong>Uterine leiomyomata (UL), hormone-dependent neoplasms, are a major source of gynecologic morbidity. Metals are hypothesized to influence UL risk through endocrine disruption, and their effects may vary by vitamin D status.</p><p><strong>Objective: </strong>We estimated associations of a metal mixture with incident UL, overall and by vitamin D status.</p><p><strong>Methods: </strong>We analyzed data from the Study of Environment, Lifestyle and Fibroids, a Detroit-area prospective cohort study of 1,693 Black women aged 23-35 years. We measured concentrations of 17 metals/metalloids in whole blood and 25-hydroxyvitamin D (25[OH]D) in serum collected at baseline (2010-2012). Participants underwent ultrasonography at baseline and after 20 months to detect UL. We used Bayesian Kernel Machine Regression to estimate adjusted associations (β) of the metal mixture with probit of incident UL. We also ran Cox regression models with interaction terms to estimate incidence rate ratios (IRR) by vitamin D status.</p><p><strong>Results: </strong>Among 1,132 UL-free participants at baseline, 832 (73%) had vitamin D deficiency (25[OH]D<20 ng/mL) and 117 (10%) developed UL within 20 months. Increasing all metals from their 50<sup>th</sup> to 75<sup>th</sup> percentiles was weakly positively associated with UL overall (β=0.06, 95% credible interval [CrI]: -0.03, 0.16) and among vitamin D-deficient participants (β=0.13, 95% CrI: 0.01, 0.24), driven by cadmium (overall and vitamin D-deficient) and mercury (vitamin D-deficient only). Increasing cadmium from its 25<sup>th</sup> to 75<sup>th</sup> percentile was positively associated with UL overall (β=0.03, 95% CrI: -0.05, 0.11) and among vitamin D-deficient participants (β=0.13, 95% CrI: 0.02, 0.24). In Cox models, cadmium (IRR=1.55, 95% confidence interval [CI]: 1.07, 2.24, per 1-unit increase in standardized concentration) and mercury (IRR=1.38, 95% CI: 0.99, 1.92) were positively associated with UL among vitamin D-deficient participants.</p><p><strong>Discussion: </strong>The metal mixture was positively associated with incident UL, but the association was weak and imprecise. We observed a stronger association among vitamin D-deficient participants that was driven by cadmium and mercury. https://doi.org/10.1289/EHP15218.</p>","PeriodicalId":11862,"journal":{"name":"Environmental Health Perspectives","volume":" ","pages":""},"PeriodicalIF":10.1,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}