Trends and Factors Related to Quality of Life in Patients with Inflammatory Bowel Disease.

IF 3.4 3区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY Gut and Liver Pub Date : 2024-11-07 DOI:10.5009/gnl240172

Sihyun Kim, Yu Kyung Jun, Yonghoon Choi, Cheol Min Shin, Young Soo Park, Nayoung Kim, Dong Ho Lee, Hyuk Yoon

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Abstract

Background/aims: Inflammatory bowel disease (IBD) affects health-related quality of life (HRQoL). The Short Inflammatory Bowel Disease Questionnaire (SIBDQ) score is strongly correlated with HRQoL in IBD patients. This study aimed to assess the factors influencing HRQoL in IBD patients.

Methods: In this prospective study, all patients with ulcerative colitis (UC) and Crohn's disease (CD) completed the SIBDQ at enrollment; some patients also completed a second SIBDQ at follow-up. Multiple linear regression analysis was used to determine associations between SIBDQ scores and clinical factors.

Results: A total of 1,020 patients participated (UC, 67%; CD, 33%). The median SIBDQ score was 52 (interquartile range, 44 to 59). In UC patients, the stool frequency (β=-2.333, p<0.001), Physician Global Assessment score (β=-3.950, p<0.001), fecal calprotectin level (β=-4.014, p<0.001), and corticosteroid use (β=-4.809, p=0.006) were negatively correlated with the SIBDQ score. In CD patients, the number of diarrhea episodes per day (β=-1.467, p=0.024) and Crohn's Disease Activity Index score (β=-0.045, p<0.001) were negatively correlated with the SIBDQ score. A total of 202 patients completed the second SIBDQ within a mean of 3.4 years. The distributions of SIBDQ score changes were as follows: decrease >10%, 28%; -10%10%, 43%. In both the initial SIBDQ and follow-up SIBDQ, scores for items pertaining to systemic symptoms (tension and fatigue) were relatively low.

Conclusions: Bowel movement-related problems significantly affect the HRQoL of both UC and CD patients. IBD patients scored lower on SIBDQ items related to general well-being. After 3 years of follow-up at the IBD clinic, 43% of patients showed a significant improvement in HRQoL.

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与炎症性肠病患者生活质量相关的趋势和因素。

背景/目的：炎症性肠病（IBD）会影响与健康相关的生活质量（HRQoL）。短期炎症性肠病问卷（SIBDQ）得分与 IBD 患者的 HRQoL 密切相关。本研究旨在评估影响 IBD 患者 HRQoL 的因素：在这项前瞻性研究中，所有溃疡性结肠炎（UC）和克罗恩病（CD）患者在入组时都填写了 SIBDQ；部分患者在随访时还填写了第二份 SIBDQ。采用多元线性回归分析确定 SIBDQ 分数与临床因素之间的关系：共有 1,020 名患者参与（UC，67%；CD，33%）。SIBDQ 评分的中位数为 52（四分位间范围为 44 至 59）。在 UC 患者中，大便次数（β=-2.333，p10%，28%；-10%10%，43%；-10%10%，43%；-10%10%，43%；-10%10%，43%；-10%10%，43%；-10%10%，43%；-10%10%，43%。在最初的 SIBDQ 和后续的 SIBDQ 中，与全身症状（紧张和疲劳）有关的项目得分相对较低：结论：排便相关问题严重影响了 UC 和 CD 患者的 HRQoL。IBD患者在SIBDQ中与一般幸福感相关的项目上得分较低。在 IBD 诊所随访 3 年后，43% 的患者的 HRQoL 有了明显改善。

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来源期刊

Gut and Liver 医学-胃肠肝病学

CiteScore

7.50

自引率

8.80%

发文量

119

审稿时长

6-12 weeks

期刊介绍： Gut and Liver is an international journal of gastroenterology, focusing on the gastrointestinal tract, liver, biliary tree, pancreas, motility, and neurogastroenterology. Gut and Liver delivers up-to-date, authoritative papers on both clinical and research-based topics in gastroenterology. The Journal publishes original articles, case reports, brief communications, letters to the editor and invited review articles in the field of gastroenterology. The Journal is operated by internationally renowned editorial boards and designed to provide a global opportunity to promote academic developments in the field of gastroenterology and hepatology. Gut and Liver is jointly owned and operated by 8 affiliated societies in the field of gastroenterology, namely: the Korean Society of Gastroenterology, the Korean Society of Gastrointestinal Endoscopy, the Korean Society of Neurogastroenterology and Motility, the Korean College of Helicobacter and Upper Gastrointestinal Research, the Korean Association for the Study of Intestinal Diseases, the Korean Association for the Study of the Liver, the Korean Pancreatobiliary Association, and the Korean Society of Gastrointestinal Cancer.