Cerebral blood flow and arterial transit time responses to exercise training in older adults.

IF 4.7 2区医学 Q1 NEUROIMAGING NeuroImage Pub Date : 2024-11-04 DOI:10.1016/j.neuroimage.2024.120919

Jack Feron, Foyzul Rahman, Sindre H Fosstveit, Kelsey E Joyce, Ahmed Gilani, Hilde Lohne-Seiler, Sveinung Berntsen, Karen J Mullinger, Katrien Segaert, Samuel J E Lucas

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Abstract

Brain vascular health worsens with age, as is made evident by resting grey matter cerebral blood flow (CBF_GM) reductions and lengthening arterial transit time (ATT_GM). Exercise training can improve aspects of brain health in older adults, yet its effects on CBF_GM and ATT_GM remain unclear. This randomised controlled trial assessed responses of CBF_GM and ATT_GM to a 26 week exercise intervention in 65 healthy older adults (control: n = 33, exercise: n = 32, aged 60-81 years), including whether changes in CBF_GM or ATT_GM were associated with cognitive function changes. Multiple-delay pseudo-continuous arterial spin labelling data were used to estimate resting global and regional CBF_GM and ATT_GM. Results showed no between-group differences in CBF_GM or ATT_GM following the intervention. However, exercise participants with the greatest cardiorespiratory gains (n = 17; ∆V̇O_2peak >2 mL/kg/min) experienced global CBF_GM reductions (-4.0 [-7.3, -0.8] mL/100 g/min). Cognitive functions did not change in either group and changes were not associated with changes in CBF_GM or ATT_GM. Our findings indicate that exercise training in older adults may induce global CBF_GM reductions when high cardiorespiratory fitness gains are induced, but this does not appear to affect cognitive functions.

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老年人对运动训练的脑血流量和动脉转运时间反应。

脑血管健康会随着年龄的增长而恶化，这一点从静息灰质脑血流量（CBFGM）的减少和动脉转运时间（ATTGM）的延长可以明显看出。运动训练可以改善老年人大脑健康的各个方面，但其对 CBFGM 和 ATTGM 的影响仍不明确。这项随机对照试验评估了 CBFGM 和 ATTGM 对 65 名健康老年人（对照组：33 人，运动组：32 人，年龄 60-81 岁）为期 26 周的运动干预的反应，包括 CBFGM 或 ATTGM 的变化是否与认知功能的变化相关。多延迟伪连续动脉自旋标记数据用于估算静息时全球和区域 CBFGM 和 ATTGM。结果显示，干预后的 CBFGM 或 ATTGM 在组间无差异。然而，心肺功能提升最大的运动参与者（n = 17；∆V 最大氧峰 >2 mL/kg/min）的整体 CBFGM 有所下降（-4.0 [-7.3, -0.8] mL/100 g/min）。两组的认知功能均未发生变化，且变化与 CBFGM 或 ATTGM 的变化无关。我们的研究结果表明，当心肺功能提高时，老年人的运动训练可能会引起CBFGM的全面下降，但这似乎不会影响认知功能。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

NeuroImage 医学-核医学

CiteScore

11.30

自引率

10.50%

发文量

809

审稿时长

63 days

期刊介绍： NeuroImage, a Journal of Brain Function provides a vehicle for communicating important advances in acquiring, analyzing, and modelling neuroimaging data and in applying these techniques to the study of structure-function and brain-behavior relationships. Though the emphasis is on the macroscopic level of human brain organization, meso-and microscopic neuroimaging across all species will be considered if informative for understanding the aforementioned relationships.