Lethal Disseminated Mucorales Infection With Positive Blood Cultures With Purpura Fulminans Complicating Hemophagocytic Lymphohistiocytosis After Chimeric Antigen Receptor T-Cell Therapy.

IF 3.8 4区 医学 Q2 IMMUNOLOGY Open Forum Infectious Diseases Pub Date : 2024-10-29 eCollection Date: 2024-11-01 DOI:10.1093/ofid/ofae647
Takahiro Matsuo, Sebastian Wurster, Doina Ivan, Rachel Hicklen, Kelly McConn, Kelli A Bagwell, Fareed Khawaja, Roy F Chemaly, Dimitrios P Kontoyiannis
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Abstract

We report a case of fulminant Mucorales fungemia in a heavily immunosuppressed cancer patient with hemophagocytic lymphohistiocytosis following CD70-targeted chimeric antigen receptor T-cell therapy. Although rare, Mucorales can cause true fungemia in a broad spectrum of hosts, with a range of manifestations from isolated fungemia to fungemia being part of widely disseminated, high-burden infection.

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嵌合抗原受体 T 细胞疗法后,致命的播散性粘菌感染伴有血培养阳性和富贵病紫癜,并发嗜血细胞淋巴组织细胞增多症
我们报告了一例重度免疫抑制的癌症患者在接受CD70靶向嵌合抗原受体T细胞治疗后,因嗜血细胞性淋巴组织细胞增多症而出现的恶性真菌血症。粘孢子菌虽然罕见,但可在广泛的宿主中引起真正的真菌血症,表现范围从孤立的真菌血症到作为广泛传播、高负担感染一部分的真菌血症。
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来源期刊
Open Forum Infectious Diseases
Open Forum Infectious Diseases Medicine-Neurology (clinical)
CiteScore
6.70
自引率
4.80%
发文量
630
审稿时长
9 weeks
期刊介绍: Open Forum Infectious Diseases provides a global forum for the publication of clinical, translational, and basic research findings in a fully open access, online journal environment. The journal reflects the broad diversity of the field of infectious diseases, and focuses on the intersection of biomedical science and clinical practice, with a particular emphasis on knowledge that holds the potential to improve patient care in populations around the world. Fully peer-reviewed, OFID supports the international community of infectious diseases experts by providing a venue for articles that further the understanding of all aspects of infectious diseases.
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