Vitamin C intake and osteoarthritis: findings of NHANES 2003-2018 and Mendelian randomization study.

IF 4 2区农林科学 Q2 NUTRITION & DIETETICS Frontiers in Nutrition Pub Date : 2024-10-23 eCollection Date: 2024-01-01 DOI:10.3389/fnut.2024.1409578

Hongjie Zhang, Xuan Jiang, Lei Bai, Jiahui Chen, Wei Luo, Jianxiong Ma, Xinlong Ma

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Abstract

Background: The role of vitamin C in osteoarthritis (OA) is still a subject of debate. Our aim was to combine the National Health and Nutrition Examination Survey (NHANES) and MR studies to explore the relationship between vitamin C intake and OA.

Methods: Clinical information on participants during NHANES 2003-2018 was collected and the relationship between vitamin C intake and OA risk was assessed using logistic regression modelling. In MR analyses, three methods were used to explore the causality of vitamin C intake with OA. Sensitivity analysis to verify the stability of the MR study.

Results: The cross-sectional study included a total of 31,527 participants, categorizing them into low (<30.2 mg), medium (30.2-93.0 mg) and high (>93.0 mg) level groups based on their vitamin C intake levels. Logistic regression models showed that vitamin C intake was not associated with OA risk (p > 0.05). Inverse-variance weighted (IVW) method of MR study showed no causality between vitamin C intake and OA (OR = 0.993, 95% CI: 0.901 ~ 1.095, p = 0.882). Sensitivity analysis indicated that the MR study was reliable.

Conclusion: Our cross-sectional and MR studies showed that vitamin C intake was not associated with OA risk. More researches are needed in the future to investigate the link between vitamin C and OA.

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维生素 C 摄入量与骨关节炎：NHANES 2003-2018 和孟德尔随机研究的结果。

背景：维生素 C 在骨关节炎（OA）中的作用仍存在争议。我们的目的是结合美国国家健康与营养调查（NHANES）和MR研究，探讨维生素C摄入量与OA之间的关系：方法：收集2003-2018年NHANES期间参与者的临床信息，并使用逻辑回归模型评估维生素C摄入量与OA风险之间的关系。在MR分析中，使用了三种方法来探讨维生素C摄入量与OA的因果关系。敏感性分析验证了 MR 研究的稳定性：该横断面研究共纳入31527名参与者，根据他们的维生素C摄入水平将其分为低（93.0毫克）水平组。逻辑回归模型显示，维生素 C 摄入量与 OA 风险无关（P > 0.05）。MR研究的逆方差加权（IVW）法显示，维生素C摄入量与OA之间没有因果关系（OR = 0.993，95% CI：0.901 ~ 1.095，P = 0.882）。敏感性分析表明，磁共振研究是可靠的：我们的横断面研究和 MR 研究表明，维生素 C 摄入量与 OA 风险无关。结论：我们的横断面研究和磁共振研究表明，维生素 C 摄入量与 OA 风险无关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Nutrition Agricultural and Biological Sciences-Food Science

CiteScore

5.20

自引率

8.00%

发文量

2891

审稿时长

12 weeks

期刊介绍： No subject pertains more to human life than nutrition. The aim of Frontiers in Nutrition is to integrate major scientific disciplines in this vast field in order to address the most relevant and pertinent questions and developments. Our ambition is to create an integrated podium based on original research, clinical trials, and contemporary reviews to build a reputable knowledge forum in the domains of human health, dietary behaviors, agronomy & 21st century food science. Through the recognized open-access Frontiers platform we welcome manuscripts to our dedicated sections relating to different areas in the field of nutrition with a focus on human health. Specialty sections in Frontiers in Nutrition include, for example, Clinical Nutrition, Nutrition & Sustainable Diets, Nutrition and Food Science Technology, Nutrition Methodology, Sport & Exercise Nutrition, Food Chemistry, and Nutritional Immunology. Based on the publication of rigorous scientific research, we thrive to achieve a visible impact on the global nutrition agenda addressing the grand challenges of our time, including obesity, malnutrition, hunger, food waste, sustainability and consumer health.