Identification and functional network analysis of inflammatory and apoptosis-related genes associated with infectious chronic rhinosinusitis: Thermal modeling of medical biological systems

IF 5.1 3区工程技术 Q2 ENERGY & FUELS Thermal Science and Engineering Progress Pub Date : 2024-11-03 DOI:10.1016/j.tsep.2024.103032

Ying Jiang , Xiaofang Du , Junhong Chen , Mengya Liu , Fan Wang , Bing Wang

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Abstract

The aim of this study was to identify inflammatory and apoptotic genes associated with infectious chronic sinusitis and to analyze their functional networks in medical biological systems by thermal modeling. Bioinformatics analysis was used to identify genes involved in apoptosis and inflammation and construct their functional networks. Finally, thermal modeling techniques were used to explore the dynamic changes of these genes in the pathogenesis of chronic sinusitis. In a comparative analysis, thermal modeling analysis revealed that these genes play important roles in apoptosis, immune response, and inflammatory signaling pathways. In addition, the heat model also revealed the interaction network between different genes, providing a new perspective for understanding the coordination mechanism of inflammation and apoptosis. Through the identification of genes associated with infectious chronic sinusitis and thermal modeling analysis of their functional networks, this study revealed the complex interaction between apoptosis and inflammation in the disease process.

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与传染性慢性鼻炎有关的炎症和细胞凋亡相关基因的鉴定和功能网络分析医学生物系统热建模

本研究旨在确定与传染性慢性鼻窦炎相关的炎症和凋亡基因，并通过热建模分析其在医学生物系统中的功能网络。通过生物信息学分析，确定了参与凋亡和炎症的基因，并构建了它们的功能网络。最后，利用热建模技术探讨了这些基因在慢性鼻窦炎发病机制中的动态变化。通过对比分析，热模型分析发现这些基因在细胞凋亡、免疫反应和炎症信号通路中发挥着重要作用。此外，热模型还揭示了不同基因之间的相互作用网络，为理解炎症和细胞凋亡的协调机制提供了新的视角。本研究通过对感染性慢性鼻窦炎相关基因的鉴定及其功能网络的热模型分析，揭示了疾病过程中细胞凋亡与炎症之间复杂的相互作用。

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来源期刊

Thermal Science and Engineering Progress Chemical Engineering-Fluid Flow and Transfer Processes

CiteScore

7.20

自引率

10.40%

发文量

327

审稿时长

41 days

期刊介绍： Thermal Science and Engineering Progress (TSEP) publishes original, high-quality research articles that span activities ranging from fundamental scientific research and discussion of the more controversial thermodynamic theories, to developments in thermal engineering that are in many instances examples of the way scientists and engineers are addressing the challenges facing a growing population – smart cities and global warming – maximising thermodynamic efficiencies and minimising all heat losses. It is intended that these will be of current relevance and interest to industry, academia and other practitioners. It is evident that many specialised journals in thermal and, to some extent, in fluid disciplines tend to focus on topics that can be classified as fundamental in nature, or are ‘applied’ and near-market. Thermal Science and Engineering Progress will bridge the gap between these two areas, allowing authors to make an easy choice, should they or a journal editor feel that their papers are ‘out of scope’ when considering other journals. The range of topics covered by Thermal Science and Engineering Progress addresses the rapid rate of development being made in thermal transfer processes as they affect traditional fields, and important growth in the topical research areas of aerospace, thermal biological and medical systems, electronics and nano-technologies, renewable energy systems, food production (including agriculture), and the need to minimise man-made thermal impacts on climate change. Review articles on appropriate topics for TSEP are encouraged, although until TSEP is fully established, these will be limited in number. Before submitting such articles, please contact one of the Editors, or a member of the Editorial Advisory Board with an outline of your proposal and your expertise in the area of your review.