Halogen-bond mediated charge transfer for visual competitive colorimetric detection of fentanyl

IF 2.6 3区医学 Q2 CHEMISTRY, ANALYTICAL Forensic Chemistry Pub Date : 2024-11-03 DOI:10.1016/j.forc.2024.100618

Boyan Li , Qiongyao Ning , Wenyou Ye , Qianxi Wang , Haili Yu , Xuecheng Chen , Yi He

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Abstract

Colorimetric assays are inexpensive and attractive tools for the detection of fentanyl (FTN), yet further enhancing their sensitivity remains a major challenge. Herein, we develop a halogen-bond mediated visual competitive colorimetric assay for FTN using Erythrosine B (EB) as a probe. The addition of poly(ethylene oxide)-block-poly(propylene oxide)-block-poly(ethylene oxide (F-127) induces the EB aggregation, strongly suppressing the background signal. Upon the introduction of FTN, the subsequent competitive reaction displaces F-127 to generate EB-FTN charge-transfer complexes via N^…I halogen bonds between electron-rich amine groups and electron-deficient iodine sites, accompanying a significant absorbance wavelength shift and pink-to-purple color change. The limits of detection of this approach for FTN are 2 mg·L⁻¹ by the naked eye and 0.19 mg·L⁻¹ by UV–vis spectroscopy, which are approximately 3.7-fold to 4 orders of magnitude more sensitive than the reported colorimetric assays. Meanwhile, the present method is well applied for FTN-spiked domestic sewage samples, and an easy-to-use smartphone-based digital image colorimetry is also fabricated. It is expected that such an assay can play a key role in alleviating the worldwide opioid overdose crisis.

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卤素键介导的电荷转移用于芬太尼的视觉竞争性比色检测

比色测定法是检测芬太尼（FTN）的廉价而有吸引力的工具，但进一步提高其灵敏度仍是一项重大挑战。在此，我们以赤藓红 B（EB）为探针，开发了一种卤素键介导的视觉竞争比色法检测 FTN。加入聚（环氧乙烷）-块状-聚（环氧丙烷）-块状-聚（环氧乙烷）（F-127）可诱导 EB 聚合，从而强烈抑制背景信号。引入 FTN 后，随后的竞争反应会置换 F-127，通过富电子胺基团和缺电子碘位点之间的 N...I 卤素键生成 EB-FTN 电荷转移复合物，伴随着显著的吸光波长偏移和粉红色到紫色的颜色变化。这种方法对芴甲氧羰基的检测限为肉眼 2 mg-L-1，紫外可见光谱 0.19 mg-L-1，比已报道的比色法灵敏度高出约 3.7 倍至 4 个数量级。同时，本方法还能很好地应用于添加了 FTN 的生活污水样品，并制作了一种易于使用的基于智能手机的数字图像比色法。这种检测方法有望在缓解全球阿片类药物过量危机方面发挥关键作用。

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来源期刊

Forensic Chemistry CHEMISTRY, ANALYTICAL-

CiteScore

5.70

自引率

14.80%

发文量

审稿时长

46 days

期刊介绍： Forensic Chemistry publishes high quality manuscripts focusing on the theory, research and application of any chemical science to forensic analysis. The scope of the journal includes fundamental advancements that result in a better understanding of the evidentiary significance derived from the physical and chemical analysis of materials. The scope of Forensic Chemistry will also include the application and or development of any molecular and atomic spectrochemical technique, electrochemical techniques, sensors, surface characterization techniques, mass spectrometry, nuclear magnetic resonance, chemometrics and statistics, and separation sciences (e.g. chromatography) that provide insight into the forensic analysis of materials. Evidential topics of interest to the journal include, but are not limited to, fingerprint analysis, drug analysis, ignitable liquid residue analysis, explosives detection and analysis, the characterization and comparison of trace evidence (glass, fibers, paints and polymers, tapes, soils and other materials), ink and paper analysis, gunshot residue analysis, synthetic pathways for drugs, toxicology and the analysis and chemistry associated with the components of fingermarks. The journal is particularly interested in receiving manuscripts that report advances in the forensic interpretation of chemical evidence. Technology Readiness Level: When submitting an article to Forensic Chemistry, all authors will be asked to self-assign a Technology Readiness Level (TRL) to their article. The purpose of the TRL system is to help readers understand the level of maturity of an idea or method, to help track the evolution of readiness of a given technique or method, and to help filter published articles by the expected ease of implementation in an operation setting within a crime lab.