Septin dynamics and organization in mammalian cells

IF 6 2区 生物学 Q1 CELL BIOLOGY Current Opinion in Cell Biology Pub Date : 2024-11-06 DOI:10.1016/j.ceb.2024.102442
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Abstract

Septins are involved in many important cellular processes, and septin dysfunction has been implicated in various pathologies, such as cancer. Like other components of the cytoskeleton -F-actin, microtubules, and intermediate filaments-septins can self-assemble into filaments and higher-order structures. These non-polar filaments are assembled from complex and variable multimeric building blocks. Septins exhibit a distinct preference for interacting with actin and microtubule structures, particularly at the interface with cellular membrane. Although they are crucial for many vital cellular functions and are frequently observed at prominent cellular structures like stress fibers, cilia, and neuronal processes, our understanding of the regulation of septin filament dynamics and the organized assembly of higher-order structures remains limited. However, recent insights into the architecture of septin filaments, the structure of crucial septin domains, and their interactions with other cellular components (F-actin, microtubules, membranes) and regulatory proteins may now pave the way for rapid progress.
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哺乳动物细胞中的蛋白酶动力学和组织结构
七联蛋白参与了许多重要的细胞过程,七联蛋白功能障碍与癌症等多种病症有关。与细胞骨架的其他成分(F-肌动蛋白、微管和中间丝)一样,七肽也能自我组装成丝和高阶结构。这些非极性细丝由复杂多变的多聚体构建模块组装而成。七肽表现出与肌动蛋白和微管结构相互作用的独特偏好,尤其是在与细胞膜的界面上。虽然它们对许多重要的细胞功能至关重要,而且经常在应力纤维、纤毛和神经元过程等突出的细胞结构中观察到它们的存在,但我们对隔膜蛋白丝动态调控和高阶结构有组织组装的了解仍然有限。不过,最近我们对 septin 细丝的结构、关键 septin 结构域的结构以及它们与其他细胞成分(F-肌动蛋白、微管、膜)和调控蛋白的相互作用有了深入的了解,这可能会为我们取得快速进展铺平道路。
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来源期刊
Current Opinion in Cell Biology
Current Opinion in Cell Biology 生物-细胞生物学
CiteScore
14.60
自引率
1.30%
发文量
79
审稿时长
93 days
期刊介绍: Current Opinion in Cell Biology (COCEBI) is a highly respected journal that specializes in publishing authoritative, comprehensive, and systematic reviews in the field of cell biology. The journal's primary aim is to provide a clear and readable synthesis of the latest advances in cell biology, helping specialists stay current with the rapidly evolving field. Expert authors contribute to the journal by annotating and highlighting the most significant papers from the extensive body of research published annually, offering valuable insights and saving time for readers by distilling key findings. COCEBI is part of the Current Opinion and Research (CO+RE) suite of journals, which leverages the legacy of editorial excellence, high impact, and global reach to ensure that the journal is a widely read resource integral to scientists' workflow. It is published by Elsevier, a publisher known for its commitment to excellence in scientific publishing and the communication of reproducible biomedical research aimed at improving human health. The journal's content is designed to be an invaluable resource for a diverse audience, including researchers, lecturers, teachers, professionals, policymakers, and students.
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