Synergistic integration of plant derived galactomannan and MXene to produce multifunctional nanocomposites with antibacterial and osteogenic properties

IF 4.1 2区 化学 Q2 POLYMER SCIENCE Polymer Pub Date : 2024-11-07 DOI:10.1016/j.polymer.2024.127799
Sinduja Malarkodi Elangovan, Riza Paul, Parthiban Shanmugam, Gopal Shankar Krishnakumar
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Abstract

This study proposes to combine plant-derived galactomannan and MXene to form an organic-inorganic hydrogel network with integrative antibacterial and osteogenic properties. Oxidized galactomannan (OxGa) was blended with N-succinyl chitosan (NSC) and varying concentrations of Mxene, owing to its high reactivity and biocompatibility. The results indicated that Mxene-loaded OxGa/NSC scaffolds exhibited biomimetic topography, adequate mechanical features and excellent physicochemical properties with strong antibacterial properties against pathogenic microbes. The cell culture experiments showed dose-dependent cytotoxic behaviour. An optimized MXene content of ≤ 4 mg/ml revealed no cytotoxicity and augmented the proliferation of osteoblast cells. Similar results were obtained in gene expression analysis where ALP, COL1A1, RUNX2, and SOX2 genes showed up-regulation. In addition, the chorioallantoic membrane (CAM) assay also illustrated augmentation of angiogenesis without any toxicity. The overall results highlight the dual performance of OxGa/NSC-MXene scaffolds to exhibit anti-infection with simultaneous osteogenic properties, which is purely determined by the concentration of MXene. Therefore, regulating MXene concentration can serve as a chemical switch in imparting adequate antibacterial functions with the ability to allow new osseous generation. Our findings on the newly designed Mxene-loaded OxGa/NSC scaffolds can be a promising biomaterial for bone-related infections with a concurrent ability to promote osteogenesis.

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协同整合植物提取的半乳甘露聚糖和 MXene,生产出具有抗菌和成骨特性的多功能纳米复合材料
本研究拟将植物提取的半乳甘露聚糖和 MXene 结合起来,形成一种具有抗菌和成骨综合特性的有机-无机水凝胶网络。氧化半乳甘露聚糖(OxGa)与 N-琥珀酰壳聚糖(NSC)和不同浓度的 Mxene 相混合,因为 Mxene 具有高反应活性和生物相容性。结果表明,Mxene负载的OxGa/NSC支架具有仿生物形貌、适当的机械特性和优异的理化性能,对病原微生物具有很强的抗菌性。细胞培养实验显示了剂量依赖性细胞毒性行为。优化后的 MXene 含量≤ 4 mg/ml 时没有细胞毒性,并能促进成骨细胞的增殖。基因表达分析也得出了类似的结果,ALP、COL1A1、RUNX2 和 SOX2 基因出现上调。此外,绒毛膜(CAM)试验也显示了血管生成的增强,且无任何毒性。总体结果凸显了 OxGa/NSC-MXene 支架在抗感染的同时具有成骨特性的双重性能,而这完全取决于 MXene 的浓度。因此,调节 MXene 的浓度可作为一种化学开关,在赋予其充分抗菌功能的同时,还能允许新骨生成。我们对新设计的 MXene 负载 OxGa/NSC 支架的研究结果表明,它是一种很有前景的生物材料,可用于治疗与骨相关的感染,同时还能促进骨生成。
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来源期刊
Polymer
Polymer 化学-高分子科学
CiteScore
7.90
自引率
8.70%
发文量
959
审稿时长
32 days
期刊介绍: Polymer is an interdisciplinary journal dedicated to publishing innovative and significant advances in Polymer Physics, Chemistry and Technology. We welcome submissions on polymer hybrids, nanocomposites, characterisation and self-assembly. Polymer also publishes work on the technological application of polymers in energy and optoelectronics. The main scope is covered but not limited to the following core areas: Polymer Materials Nanocomposites and hybrid nanomaterials Polymer blends, films, fibres, networks and porous materials Physical Characterization Characterisation, modelling and simulation* of molecular and materials properties in bulk, solution, and thin films Polymer Engineering Advanced multiscale processing methods Polymer Synthesis, Modification and Self-assembly Including designer polymer architectures, mechanisms and kinetics, and supramolecular polymerization Technological Applications Polymers for energy generation and storage Polymer membranes for separation technology Polymers for opto- and microelectronics.
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