Mef2d: a novel transcription factor in type 2 allergic lung inflammation

IF 40.8 1区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Signal Transduction and Targeted Therapy Pub Date : 2024-11-07 DOI:10.1038/s41392-024-02022-9
Laura Surace, Christoph Wilhelm, Christian Bode
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Abstract

In a recent article published in Science, Szeto et al. identified myocyte-specific enhancer factor 2d (Mef2d) as a promoter of type 2 immunity and allergic lung inflammation. Using CRISPR screens and orthogonal recombinase-enabled Boolean gene circuitry, the authors revealed that Mef2d modulates GATA3 expression by suppressing Regnase-1, thereby boosting IL-33 signaling and cytokine production.1

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Mef2d:2型过敏性肺部炎症中的新型转录因子
最近,Szeto 等人在《科学》(Science)杂志上发表文章,指出肌细胞特异性增强因子 2d(Mef2d)是 2 型免疫和过敏性肺部炎症的启动子。作者利用 CRISPR 筛选和正交重组酶驱动的布尔基因回路,发现 Mef2d 通过抑制 Regnase-1 来调节 GATA3 的表达,从而促进 IL-33 信号传导和细胞因子的产生。
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来源期刊
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy Biochemistry, Genetics and Molecular Biology-Genetics
CiteScore
44.50
自引率
1.50%
发文量
384
审稿时长
5 weeks
期刊介绍: Signal Transduction and Targeted Therapy is an open access journal that focuses on timely publication of cutting-edge discoveries and advancements in basic science and clinical research related to signal transduction and targeted therapy. Scope: The journal covers research on major human diseases, including, but not limited to: Cancer,Cardiovascular diseases,Autoimmune diseases,Nervous system diseases.
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