{"title":"Early intermittent cholesterol exposure accelerates atherosclerosis: an oscillating amplifier calling for preemptive control","authors":"Maria Kral, Yvonne Döring, Christian Weber","doi":"10.1038/s41392-024-02032-7","DOIUrl":null,"url":null,"abstract":"<p>A recent publication in <i>Nature</i><sup>1</sup> identified early intermittent hyperlipidemia as a new determinant of atherosclerosis driving an altered phenotype of arterial-resident macrophages with defects in autophagy- and efferocytosis-related pathways. These intriguing findings infer the need for preemptive control of cholesterol already at younger age to prevent and limit atherosclerosis.</p>","PeriodicalId":21766,"journal":{"name":"Signal Transduction and Targeted Therapy","volume":null,"pages":null},"PeriodicalIF":40.8000,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Signal Transduction and Targeted Therapy","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1038/s41392-024-02032-7","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
A recent publication in Nature1 identified early intermittent hyperlipidemia as a new determinant of atherosclerosis driving an altered phenotype of arterial-resident macrophages with defects in autophagy- and efferocytosis-related pathways. These intriguing findings infer the need for preemptive control of cholesterol already at younger age to prevent and limit atherosclerosis.
期刊介绍：
Signal Transduction and Targeted Therapy is an open access journal that focuses on timely publication of cutting-edge discoveries and advancements in basic science and clinical research related to signal transduction and targeted therapy.
Scope: The journal covers research on major human diseases, including, but not limited to:
Cancer,Cardiovascular diseases,Autoimmune diseases,Nervous system diseases.
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