An electrochemiluminescence sensor for ultrasensitive determination tyrosine based on ceria nanomaterial as a novel luminophor

IF 5.7 2区 化学 Q1 CHEMISTRY, ANALYTICAL Analytica Chimica Acta Pub Date : 2024-11-07 DOI:10.1016/j.aca.2024.343388
Yaxuan Qian, Zhihua Wang
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Abstract

Backgroud

Recently, optical nanomaterials have attracted much attention in the field of electrochemiluminescence (ECL). Nanostructured ceria possessed unique optical properties, and it’s always used for constructing ECL sensor as catalyst for improving sensing performance, while the ECL property of ceria is rarely studied. In fact, it could be the potential candidate for applying in ECL sensors based on size and shape dependency optical property caused by the quantum scale effects. Therefore, new simple and efficient ceria nanomaterial used as luminophor for constructing the ECL sensor have aroused more research interest and motivation. (91 words)

Results

In the work, three kinds of nanostructured ceria, ceria nano-cube (CeO2-NC), ceria nano-rods (CeO2-NR) and ceria nano-particle (CeO2-NP), have been prepared by hydrothermal method, and CeO2-NC with the less oxygen vacancy has the highest ECL signal. Moreover, how the shape affects the ECL property was investigated in detail, especially the oxygen vacancy on the surface of the ceria. The less of oxygen vacancy content of CeO2 nanomaterials is more favorable the ECL reaction. Furthermore, a novel ECL sensor was constructed based on reduced graphene oxide (rGO), Au nano-particle (AuNPs) and CeO2-NC for Tyrosine (Tyr) determination owing to the electron transform between the luminous of ceria and Tyr resulting in the cathodic ECL intensity quenched correspondingly, and it has possessed excellent sensing performance with a linear range of 0.005 ∼ 20 nmol/L and the limit of detection (LOD) value of 1.7 fmol/L. (141 words)

Significance and Novelty

The proposed method demonstrated excellent selectivity and ultra-sensitivity toward Tyr, which had been used for the determination of Tyr in human serum successfully, possessing outstanding analytical performance. Therefore, nanostructured ceria is a new category of efficient and promising luminophore, which would open new avenues for the potential application in the field of ECL sensing for clinical diagnosis. (57 words)

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基于铈纳米材料作为新型发光体的超灵敏测定酪氨酸的电化学发光传感器
背景介绍近年来,光学纳米材料在电致化学发光(ECL)领域备受关注。纳米结构铈具有独特的光学特性,一直被用作构建电致化学发光传感器的催化剂以提高传感性能,但对铈的电致化学发光特性研究却很少。事实上,基于量子尺度效应导致的尺寸和形状依赖性光学特性,铈有可能成为应用于 ECL 传感器的潜在候选材料。因此,用简单高效的新型铈纳米材料作为发光体来构建 ECL 传感器引起了更多的研究兴趣和动力。(91个字)结果该研究采用水热法制备了三种纳米结构的铈,即纳米立方铈(CeO2-NC)、纳米棒状铈(CeO2-NR)和纳米颗粒铈(CeO2-NP),其中氧空位较少的 CeO2-NC 具有最高的 ECL 信号。此外,还详细研究了形状对 ECL 特性的影响,尤其是铈表面的氧空位。氧空位含量越少的 CeO2 纳米材料越有利于 ECL 反应。此外,基于还原氧化石墨烯(rGO)、金纳米粒子(AuNPs)和CeO2-NC构建了一种新型的酪氨酸(Tyr)检测ECL传感器,由于铈发光体与Tyr之间的电子转化导致阴极ECL强度相应淬灭,该传感器具有良好的传感性能,线性范围为0.005 ∼ 20 nmol/L,检出限为1.7 fmol/L。(该方法对酪氨酸具有良好的选择性和超灵敏度,已成功用于人血清中酪氨酸的测定,分析性能优异。因此,纳米结构铈是一种新型高效、前景广阔的发光体,它将为ECL传感在临床诊断领域的潜在应用开辟新的途径。(57个字)
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来源期刊
Analytica Chimica Acta
Analytica Chimica Acta 化学-分析化学
CiteScore
10.40
自引率
6.50%
发文量
1081
审稿时长
38 days
期刊介绍: Analytica Chimica Acta has an open access mirror journal Analytica Chimica Acta: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. Analytica Chimica Acta provides a forum for the rapid publication of original research, and critical, comprehensive reviews dealing with all aspects of fundamental and applied modern analytical chemistry. The journal welcomes the submission of research papers which report studies concerning the development of new and significant analytical methodologies. In determining the suitability of submitted articles for publication, particular scrutiny will be placed on the degree of novelty and impact of the research and the extent to which it adds to the existing body of knowledge in analytical chemistry.
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