A review on Ti3C2Tx based nanocomposites for the electrochemical sensing of clinically relevant biomarkers

IF 3.5 Q2 CHEMISTRY, ANALYTICAL Sensors & diagnostics Pub Date : 2024-10-11 DOI:10.1039/D4SD00171K

Anjali Sugunan, Anusree V. Rethnakumaran and Mini Mol Menamparambath

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Abstract

Reckoning the significance of next-generation biosensors and point-of-care sensors, scientists are interested in developing superior nanomaterials with advantageous characteristics that can serve as electrode modifiers in the development of functional devices. MXenes are a broad class of two-dimensional metal carbides and nitrides characterized by their exceptional hydrophilicity, high specific surface area, and high conductivity. MXenes and their derived nanocomposites are presently gaining importance as electrode materials for the electrochemical detection of various biomarkers. This review assesses and summarises current notable accomplishments in the concepts, fabrication, and diverse applications of MXene-based nanocomposites for electrochemical monitoring of a variety of clinically relevant biomarkers. Furthermore, an outline of the existing impediments linked to technological advancement is included, accompanied by proposals for further investigation into the issues.

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基于 Ti3C2Tx 的纳米复合材料用于临床相关生物标记物电化学传感的综述

考虑到下一代生物传感器和护理点传感器的重要性，科学家们对开发具有优势特性的优质纳米材料很感兴趣，这些材料可在开发功能器件时用作电极改性剂。MXenes 是一类广泛的二维金属碳化物和氮化物，具有优异的亲水性、高比表面积和高导电性。目前，MXenes 及其衍生纳米复合材料作为电化学检测各种生物标记物的电极材料正变得越来越重要。本综述评估并总结了目前在基于 MXene 的纳米复合材料用于电化学监测各种临床相关生物标记物的概念、制造和各种应用方面取得的显著成就。此外，还概述了与技术进步相关的现有障碍，并提出了进一步研究这些问题的建议。

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