{"title":"Inclusiveness of the All of Us Research Program improves polygenic risk scores and fosters genomic medicine for all","authors":"Benson R. Kidenya, Gerald Mboowa","doi":"10.1038/s43856-024-00647-z","DOIUrl":null,"url":null,"abstract":"Polygenic risk scores (PRS) show promise but have accuracy disparities across ancestries due to underrepresentation in the existing genomic databases. Here, we outline the initiative of All of Us Research Program in refining PRS and advancing genomic medicine for all. Kidenya and Mboowa discuss the current state of genomic inclusiveness in medicine. They champion the efforts of the All of Us Research Program to broaden diversity in population genomics and reduce disparities across different ancestries.","PeriodicalId":72646,"journal":{"name":"Communications medicine","volume":null,"pages":null},"PeriodicalIF":5.4000,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s43856-024-00647-z.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Communications medicine","FirstCategoryId":"1085","ListUrlMain":"https://www.nature.com/articles/s43856-024-00647-z","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}
引用次数: 0
Abstract
Polygenic risk scores (PRS) show promise but have accuracy disparities across ancestries due to underrepresentation in the existing genomic databases. Here, we outline the initiative of All of Us Research Program in refining PRS and advancing genomic medicine for all. Kidenya and Mboowa discuss the current state of genomic inclusiveness in medicine. They champion the efforts of the All of Us Research Program to broaden diversity in population genomics and reduce disparities across different ancestries.
多基因风险评分（PRS）显示了前景，但由于在现有基因组数据库中的代表性不足，不同血统的准确性存在差异。在此，我们概述了 "我们所有人研究计划"（All of Us Research Program）在完善多基因风险评分和推进全民基因组医学方面的举措。Kidenya 和 Mboowa 讨论了基因组医学包容性的现状。他们支持 "我们所有人研究计划"（All of Us Research Program）为扩大人群基因组学的多样性和减少不同血统之间的差异所做的努力。
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