Relationship Between Mitochondrial Biological Function and Breast Cancer

IF 1.9 4区 医学 Q3 OBSTETRICS & GYNECOLOGY Breast Journal Pub Date : 2024-11-06 DOI:10.1155/2024/4434466
Shichen Miao, Qichao Ni, Jun Fang
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Abstract

Objective: This study aims to investigate the potential causal link between mitochondrial function and breast cancer using the Mendelian randomization (MR) analysis.

Methods: The data used for this study were obtained from genomewide association studies (GWAS) databases on mitochondrial biological function and breast cancer. Mitochondrial function was considered the exposure variable, breast cancer the outcome variable, and specific single nucleotide polymorphisms (SNPs) were selected as instrumental variables (IVs). Two MR methods, inverse variance weighting (IVW) and MR-Egger regression, were used to assess the causal association between mitochondrial function and breast cancer. Data analysis and visualization were performed using R software.

Results: The results of the analysis revealed that several genes, including 39S ribosomal protein L34, pyruvate carboxylase, rRNA methyltransferase 3, and cytochrome c oxidase assembly factor 3 homolog, are causally linked to an increased risk of breast cancer in European populations. In addition, cytochrome c oxidase subunit 8A and ADP-ribose pyrophosphatase were found to be protective factors against breast cancer in European populations. In East Asian populations, 39S ribosomal protein L52, ATP synthase subunit beta, and pyruvate dehydrogenase (acetyl-transferring) were identified as causal risk factors for breast cancer. Conversely, 39S ribosomal protein L32, ADP-ribose pyrophosphatase, and cytochrome c oxidase subunit 8A were identified as protective factors against breast cancer in this population.

Conclusion: In conclusion, this study provides evidence of a causal relationship between mitochondrial function and breast cancer in both European and East Asian populations. Additional research is warranted to further elucidate the mechanisms underlying this association.

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线粒体生物功能与乳腺癌的关系
研究目的本研究旨在利用孟德尔随机分析法(MR)研究线粒体功能与乳腺癌之间的潜在因果关系。 研究方法本研究使用的数据来自线粒体生物功能和乳腺癌的全基因组关联研究(GWAS)数据库。线粒体功能被视为暴露变量,乳腺癌被视为结果变量,特定的单核苷酸多态性(SNPs)被选为工具变量(IVs)。使用两种 MR 方法(逆方差加权(IVW)和 MR-Egger 回归)评估线粒体功能与乳腺癌之间的因果关系。数据分析和可视化使用 R 软件进行。 结果分析结果显示,在欧洲人群中,包括 39S 核糖体蛋白 L34、丙酮酸羧化酶、rRNA 甲基转移酶 3 和细胞色素 c 氧化酶组装因子 3 同源物在内的多个基因与乳腺癌风险的增加存在因果关系。此外,在欧洲人群中,细胞色素 c 氧化酶亚基 8A 和 ADP 核糖焦磷酸酶是乳腺癌的保护因素。在东亚人群中,39S核糖体蛋白L52、ATP合成酶亚单位β和丙酮酸脱氢酶(乙酰转移)被确定为乳腺癌的致病风险因素。相反,39S 核糖体蛋白 L32、ADP 核糖焦磷酸酶和细胞色素 c 氧化酶亚基 8A 被确定为该人群中乳腺癌的保护因素。 结论总之,本研究为欧洲和东亚人群线粒体功能与乳腺癌之间的因果关系提供了证据。为了进一步阐明这种关联的机制,还需要进行更多的研究。
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来源期刊
Breast Journal
Breast Journal 医学-妇产科学
CiteScore
4.00
自引率
0.00%
发文量
47
审稿时长
4-8 weeks
期刊介绍: The Breast Journal is the first comprehensive, multidisciplinary source devoted exclusively to all facets of research, diagnosis, and treatment of breast disease. The Breast Journal encompasses the latest news and technologies from the many medical specialties concerned with breast disease care in order to address the disease within the context of an integrated breast health care. This editorial philosophy recognizes the special social, sexual, and psychological considerations that distinguish cancer, and breast cancer in particular, from other serious diseases. Topics specifically within the scope of The Breast Journal include: Risk Factors Prevention Early Detection Diagnosis and Therapy Psychological Issues Quality of Life Biology of Breast Cancer.
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