{"title":"Mild behavioural impairment in Parkinson’s disease: a systematic review","authors":"Ruan-Ching Yu, Lung Chan, Szu-Yi Chou, Li-Fong Lin, Chaur-Jong Hu, Chien-Tai Hong","doi":"10.1093/ageing/afae247","DOIUrl":null,"url":null,"abstract":"Behavioural symptoms are common manifestations of Parkinson’s disease (PD). Early behavioural symptoms characterise mild behavioural impairment (MBI). The prevalence and intensity of MBI in people with PD (PwP) have been studied across various cohorts. However, methodological differences have obscured our understanding of MBI in these individuals. This systematic review examines and synthesises findings from relevant studies, enhancing understanding of the symptoms and implications of MBI in PD. Nine studies from five separate research institutions were identified. The conceptualisation of MBI varied considerably, affecting the reported prevalence rates of MBI in individuals with early-stage PD. Among PwP, MBI was associated higher education and impaired cognition. Affective dysregulation and impulse control disorders were primary contributors to MBI; abnormal perception was least contributor. This systematic review underscores the specific characteristics and incidence of MBI in early-stage PD. Mood and impulse control disorders are primary concerns associated with MBI. Future longitudinal studies are required to clarify the progression of these symptoms and evaluate MBI’s potential as an indicator for PD-related dementia or increased dependency.","PeriodicalId":7682,"journal":{"name":"Age and ageing","volume":null,"pages":null},"PeriodicalIF":6.0000,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Age and ageing","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1093/ageing/afae247","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"GERIATRICS & GERONTOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Behavioural symptoms are common manifestations of Parkinson’s disease (PD). Early behavioural symptoms characterise mild behavioural impairment (MBI). The prevalence and intensity of MBI in people with PD (PwP) have been studied across various cohorts. However, methodological differences have obscured our understanding of MBI in these individuals. This systematic review examines and synthesises findings from relevant studies, enhancing understanding of the symptoms and implications of MBI in PD. Nine studies from five separate research institutions were identified. The conceptualisation of MBI varied considerably, affecting the reported prevalence rates of MBI in individuals with early-stage PD. Among PwP, MBI was associated higher education and impaired cognition. Affective dysregulation and impulse control disorders were primary contributors to MBI; abnormal perception was least contributor. This systematic review underscores the specific characteristics and incidence of MBI in early-stage PD. Mood and impulse control disorders are primary concerns associated with MBI. Future longitudinal studies are required to clarify the progression of these symptoms and evaluate MBI’s potential as an indicator for PD-related dementia or increased dependency.
行为症状是帕金森病(PD)的常见表现。早期行为症状是轻度行为障碍(MBI)的特征。对帕金森病患者(PwP)轻度行为障碍的发生率和强度进行了不同队列的研究。然而,方法上的差异阻碍了我们对这些人的轻度行为障碍的了解。本系统性综述对相关研究的结果进行了检查和综合,从而加深了我们对帕金森病 MBI 症状和影响的理解。本综述确定了来自五个不同研究机构的九项研究。MBI的概念差异很大,影响了早期帕金森病患者MBI的报告患病率。在残疾人中,MBI 与教育程度较高和认知能力受损有关。情感调节障碍和冲动控制障碍是导致MBI的主要因素,而知觉异常是导致MBI的最小因素。本系统综述强调了早期帕金森病中MBI的具体特征和发病率。情绪和冲动控制障碍是与MBI相关的主要问题。未来需要进行纵向研究,以明确这些症状的进展,并评估MBI作为与帕金森病相关的痴呆症或依赖性增加的指标的潜力。
期刊介绍:
Age and Ageing is an international journal publishing refereed original articles and commissioned reviews on geriatric medicine and gerontology. Its range includes research on ageing and clinical, epidemiological, and psychological aspects of later life.