Cationic first-row transition metal saccharinate complexes with tris(2-pyridylmethyl)amine: synthesis, structures and anticancer studies†

IF 3.3 3区化学 Q2 CHEMISTRY, INORGANIC & NUCLEAR Dalton Transactions Pub Date : 2024-11-08 DOI:10.1039/D4DT02258K

Ceyda Icsel, Seyma Aydinlik, Muhittin Aygun and Veysel T. Yilmaz

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Abstract

A series of new cationic first-row transition metal complexes of [Mn(sac)(H₂O)(tpma)](sac)·H₂O (Mn), [(μ-O){FeCl(tpma)}₂](sac)₂·3H₂O (Fe), [Co(sac)(H₂O)(tpma)](sac)·H₂O (Co), [Ni(H₂O)₂(tpma)](sac)₂·2H₂O (Ni), [Cu(sac)(tpma)](sac) (Cu) and [Zn(sac)(H₂O)(tpma)](sac) (Zn), where sac = saccharinate and tpma = tris(2-pyridylmethyl)amine, were synthesized and structurally characterized by elemental analysis, UV-Vis, IR, ESI-MS, NMR, X-ray diffraction and conductivity measurements. The cytotoxic activity of the metal complexes was evaluated in vitro against lung carcinoma (A549), breast adenocarcinoma (MCF7), colon (HT29), and normal BEAS-2B cell lines. Mn and Fe displayed potent cytotoxic activity in all cell lines with IC₅₀ values between 1.99 ± 0.33 and 6.65 ± 0.67 μM, while Cu moderately affected the growth of HT29 cells. However the rest of the metal complexes did not demonstrate any growth inhibitory effect. Further studies with Fe treated HT29 cells through cellular imaging analysis indicated that Fe significantly induced intracellular ROS (reactive oxygen species) accumulation, mitochondrial dysfunction and double-strand DNA breaks, and eventually caused apoptotic cell death through the intrinsic pathway.

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三(2-吡啶基甲基)胺阳离子第一排过渡金属糖精配合物：合成、结构和抗癌研究

一系列新的阳离子第一排过渡金属配合物：[Mn(sac)(H2O)(tpma)](sac)H2O（Mn）、[(µ-O){FeCl(tpma)}2](sac)23H2O（Fe）、[Co(sac)(H2O)(tpma)](sac)H2O（Co）、[Ni(H2O)2(tpma)](sac)22H2O（Ni）、合成了[Cu(sac)(tpma)](sac)（铜）和[Zn(sac)(H2O)(tpma)](sac)（锌），其中 sac = 糖醛酸盐，tpma = 三（2-吡啶基甲基）胺，并通过元素分析、紫外可见光、红外光谱、ESI-MS、核磁共振、X 射线衍射和电导率测量对其结构进行了表征。在体外评估了金属配合物对肺癌（A549）、乳腺癌（MCF7）、结肠癌（HT29）和正常 BEAS-2B 细胞系的细胞毒活性。锰和铁在所有细胞系中都显示出了强大的细胞毒性活性，其 IC50 值介于 1.99 ± 0.33 和 6.65 ± 0.67 μM 之间，而铜对 HT29 细胞的生长影响不大。然而，其他金属复合物没有显示出任何生长抑制作用。通过细胞成像分析对铁处理的 HT29 细胞进行的进一步研究表明，铁能显著诱导细胞内 ROS（活性氧）积累、线粒体功能障碍和双链 DNA 断裂，并最终通过内在途径导致细胞凋亡。

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来源期刊

Dalton Transactions 化学-无机化学与核化学

CiteScore

6.60

自引率

7.50%

发文量

1832

审稿时长

1.5 months

期刊介绍： Dalton Transactions is a journal for all areas of inorganic chemistry, which encompasses the organometallic, bioinorganic and materials chemistry of the elements, with applications including synthesis, catalysis, energy conversion/storage, electrical devices and medicine. Dalton Transactions welcomes high-quality, original submissions in all of these areas and more, where the advancement of knowledge in inorganic chemistry is significant.