Endocisternal interfaces for minimally invasive neural stimulation and recording of the brain and spinal cord

IF 26.8 1区 医学 Q1 ENGINEERING, BIOMEDICAL Nature Biomedical Engineering Pub Date : 2024-11-11 DOI:10.1038/s41551-024-01281-9
Joshua C. Chen, Abdeali Dhuliyawalla, Robert Garcia, Ariadna Robledo, Joshua E. Woods, Fatima Alrashdan, Sean O’Leary, Adam Husain, Anthony Price, Scott Crosby, Michelle M. Felicella, Ajay K. Wakhloo, Patrick Karas, Nicole Provenza, Wayne Goodman, Sameer A. Sheth, Sunil A. Sheth, Jacob T. Robinson, Peter Kan
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Abstract

Minimally invasive neural interfaces can be used to diagnose, manage and treat many disorders, with reduced risks of surgical complications. However, endovascular probes lack access to key cortical, subcortical and spinal targets, and are not typically explantable after endothelialization. Here we report the development and testing, in sheep, of endocisternal neural interfaces that approach brain and spinal cord targets through inner and outer spaces filled with cerebrospinal fluid. Thus, the interfaces gain access to the entire brain convexity, to deep brain structures within the ventricles and to the spinal cord from the spinal subarachnoid space. We combined an endocisternal neural interface with wireless miniature magnetoelectrically powered bioelectronics so that it can be freely navigated percutaneously from the spinal space to the cranial subarachnoid space, and from the cranial subarachnoid space to the ventricles. In sheep, we show recording and stimulation functions, as well as repositioning of the flexible electrodes and explantation of the interface after chronic implantation. Minimally invasive endocisternal bioelectronics may enable chronic and transient therapies, particularly for stroke rehabilitation and epilepsy monitoring.

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用于对大脑和脊髓进行微创神经刺激和记录的腔内界面
微创神经接口可用于诊断、管理和治疗多种疾病,并降低手术并发症的风险。然而,血管内探针无法进入关键的皮层、皮层下和脊柱靶点,而且在内皮化后通常无法拆卸。在此,我们报告了在绵羊身上开发和测试内腔神经接口的情况,这种接口可通过充满脑脊液的内部和外部空间接近大脑和脊髓目标。这样,接口就能进入整个大脑凸面、脑室内的大脑深层结构以及脊髓蛛网膜下腔的脊髓。我们将内腔神经接口与无线微型磁电驱动生物电子装置相结合,使其可以从脊柱间隙经皮自由导航到颅内蛛网膜下腔,再从颅内蛛网膜下腔导航到脑室。我们在绵羊身上展示了记录和刺激功能,以及长期植入后柔性电极的重新定位和接口的拆卸。微创腔内生物电子学可实现慢性和瞬时疗法,特别是用于中风康复和癫痫监测。
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来源期刊
Nature Biomedical Engineering
Nature Biomedical Engineering Medicine-Medicine (miscellaneous)
CiteScore
45.30
自引率
1.10%
发文量
138
期刊介绍: Nature Biomedical Engineering is an online-only monthly journal that was launched in January 2017. It aims to publish original research, reviews, and commentary focusing on applied biomedicine and health technology. The journal targets a diverse audience, including life scientists who are involved in developing experimental or computational systems and methods to enhance our understanding of human physiology. It also covers biomedical researchers and engineers who are engaged in designing or optimizing therapies, assays, devices, or procedures for diagnosing or treating diseases. Additionally, clinicians, who make use of research outputs to evaluate patient health or administer therapy in various clinical settings and healthcare contexts, are also part of the target audience.
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