Harnessing curcumin and nanotechnology for enhanced treatment of breast cancer bone metastasis

IF 5.5 3区材料科学 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY Nanoscale Research Letters Pub Date : 2024-11-11 DOI:10.1186/s11671-024-04126-1

Shiva Shakori Poshteh, Shohreh Alipour, Pegah Varamini

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Abstract

Breast cancer (BC) bone metastasis poses a significant clinical challenge due to its impact on patient prognosis and quality of life. Curcumin (CUR), a natural polyphenol compound found in turmeric, has shown potential in cancer therapy due to its anti-inflammatory, antioxidant, and anticancer properties. However, its metabolic instability and hydrophobicity have hindered its clinical applications, leading to a short plasma half-life, poor absorption, and low bioavailability. To enhance the drug-like properties of CUR, nanotechnology-based delivery strategies have been employed, utilizing polymeric, lipidic, and inorganic nanoparticles (NPs). These approaches have effectively overcome CUR’s inherent limitations by enhancing its stability and cellular bioavailability both in vitro and in vivo. Moreover, targeting molecules with high selectivity towards bone metastasized breast cancer cells can be used for site specific delivery of curcumin. Alendronate (ALN), a bone-seeking bisphosphonate, is one such moiety with high selectivity towards bone and thus can be effectively used for targeted delivery of curcumin loaded nanocarriers. This review will detail the process of bone metastasis in BC, elucidate the mechanism of action of CUR, and assess the efficacy of nanotechnology-based strategies for CUR delivery. Specifically, it will focus on how these strategies enhance CUR’s stability and improve targeted delivery approaches in the treatment of BC bone metastasis.

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利用姜黄素和纳米技术加强对乳腺癌骨转移的治疗

乳腺癌（BC）骨转移对患者的预后和生活质量有很大影响，是一项重大的临床挑战。姜黄素（CUR）是一种存在于姜黄中的天然多酚化合物，因其具有抗炎、抗氧化和抗癌特性，已显示出在癌症治疗中的潜力。然而，其代谢不稳定性和疏水性阻碍了它的临床应用，导致其血浆半衰期短、吸收差和生物利用率低。为了增强 CUR 的类药物特性，人们采用了基于纳米技术的给药策略，利用聚合物、脂质和无机纳米颗粒（NPs）。这些方法有效克服了 CUR 的固有局限性，提高了其在体外和体内的稳定性和细胞生物利用度。此外，对骨转移乳腺癌细胞具有高选择性的靶向分子可用于姜黄素的特定部位给药。阿仑膦酸盐（ALN）是一种骨寻求型双膦酸盐，是对骨具有高选择性的分子之一，因此可有效用于姜黄素纳米载体的靶向递送。本综述将详细介绍 BC 骨转移的过程，阐明姜黄素的作用机制，并评估基于纳米技术的姜黄素递送策略的有效性。具体来说，它将重点关注这些策略如何增强 CUR 的稳定性，并改进治疗 BC 骨转移的靶向递送方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nanoscale Research Letters 工程技术-材料科学：综合

CiteScore

11.30

自引率

0.00%

发文量

110

审稿时长

48 days

期刊介绍： Nanoscale Research Letters (NRL) provides an interdisciplinary forum for communication of scientific and technological advances in the creation and use of objects at the nanometer scale. NRL is the first nanotechnology journal from a major publisher to be published with Open Access.