A facility for laboratory mice with a natural microbiome at Charité – Universitätsmedizin Berlin

IF 5.9 3区 农林科学 Q1 VETERINARY SCIENCES Lab Animal Pub Date : 2024-11-12 DOI:10.1038/s41684-024-01474-4
Natascha Drude, Stefan Nagel-Riedasch, Stephan P. Rosshart, Andreas Diefenbach, Stefan Jordan
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Abstract

Mice with a natural microbiome are a promising research model for basic and applied science because of their closer resemblance to the human superorganism compared to mice born and raised under stringent hygiene conditions. Consequently, biomedical therapies developed and tested in “Wildling mice” hold great potential for successful translation into clinical applications. Over the past four years, scientists, veterinarians and institutional officials at Charité – Universitätsmedizin Berlin, supported by the University Hospital Erlangen, have designed a facility for Wildling mice and developed a conceptual framework for safe and ethical preclinical research involving mice with a natural microbiome.

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柏林夏里特大学自然微生物组实验小鼠设施
与在严格的卫生条件下出生和长大的小鼠相比,具有天然微生物群的小鼠更接近于人类的超级有机体,因此是一种很有前途的基础和应用科学研究模型。因此,在 "野生小鼠 "身上开发和测试的生物医学疗法具有成功转化为临床应用的巨大潜力。在过去的四年里,柏林夏里特大学的科学家、兽医和机构官员在埃尔兰根大学医院的支持下,设计了一个野化小鼠设施,并为涉及具有天然微生物组的小鼠的安全和伦理临床前研究制定了一个概念框架。
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来源期刊
Lab Animal
Lab Animal 农林科学-兽医学
CiteScore
0.60
自引率
2.90%
发文量
181
审稿时长
>36 weeks
期刊介绍: LabAnimal is a Nature Research journal dedicated to in vivo science and technology that improves our basic understanding and use of model organisms of human health and disease. In addition to basic research, methods and technologies, LabAnimal also covers important news, business and regulatory matters that impact the development and application of model organisms for preclinical research. LabAnimal's focus is on innovative in vivo methods, research and technology covering a wide range of model organisms. Our broad scope ensures that the work we publish reaches the widest possible audience. LabAnimal provides a rigorous and fair peer review of manuscripts, high standards for copyediting and production, and efficient publication.
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