Chemical Synthesis of Globo H and Mannobiose Glycopolymers and their Immunological Stimulation

IF 4.1 2区 化学 Q2 POLYMER SCIENCE Chinese Journal of Polymer Science Pub Date : 2024-10-10 DOI:10.1007/s10118-024-3209-2
Zhi Zhang, Ce-Ce Xue, Ying-Le Feng, Guo-Song Chen
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Abstract

Tumor-associated carbohydrate antigens (TACAs) provide a special class of tumor-specific antigens that show promising applications in cancer immunotherapy. However, the weak immunogenicity and structural complexity of TACAs are obstacles to their clinical application. Here, based on a fast and low-cost purification strategy for oligosaccharide synthesis, the synthesis of tumour-associated carbohydrate antigens Globo H and mannobiose which resembles repeat unit of mannan was achieved. To enhance the immunogenicity and multivalent effect, Globo H and mannobiose were covalently attached to degradable polymer backbones. 2D spindle-like lamellar micelle and globular micelle were obtained from glycopolymer through a solvent-exchange method of self-assembly. The glyconanoparticle showed good biocompatibility and degradability. Immunological functions of these glyconanoparticles such as stimulation of BMDC to cause upregulation of inflammatory factors were preliminarily explored.

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Globo H 和甘露聚糖的化学合成及其免疫刺激作用
肿瘤相关碳水化合物抗原(TACAs)是一类特殊的肿瘤特异性抗原,在癌症免疫疗法中具有广阔的应用前景。然而,TACAs 的弱免疫原性和结构复杂性是其临床应用的障碍。本文基于快速、低成本的寡糖合成纯化策略,合成了肿瘤相关碳水化合物抗原 Globo H 和类似甘露聚糖重复单元的甘露寡糖。为了增强免疫原性和多价效应,Globo H 和甘露寡糖被共价连接到可降解聚合物骨架上。通过溶剂交换自组装方法,糖聚物获得了二维纺锤形片状胶束和球状胶束。甘聚糖颗粒具有良好的生物相容性和可降解性。初步探讨了这些甘聚糖颗粒的免疫学功能,如刺激 BMDC 引起炎症因子的上调。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Chinese Journal of Polymer Science
Chinese Journal of Polymer Science 化学-高分子科学
CiteScore
7.10
自引率
11.60%
发文量
218
审稿时长
6.0 months
期刊介绍: Chinese Journal of Polymer Science (CJPS) is a monthly journal published in English and sponsored by the Chinese Chemical Society and the Institute of Chemistry, Chinese Academy of Sciences. CJPS is edited by a distinguished Editorial Board headed by Professor Qi-Feng Zhou and supported by an International Advisory Board in which many famous active polymer scientists all over the world are included. The journal was first published in 1983 under the title Polymer Communications and has the current name since 1985. CJPS is a peer-reviewed journal dedicated to the timely publication of original research ideas and results in the field of polymer science. The issues may carry regular papers, rapid communications and notes as well as feature articles. As a leading polymer journal in China published in English, CJPS reflects the new achievements obtained in various laboratories of China, CJPS also includes papers submitted by scientists of different countries and regions outside of China, reflecting the international nature of the journal.
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