{"title":"A GSDMD agonist boosts specific antitumor immunity","authors":"Yingying Zhang, Jiahuai Han","doi":"10.1038/s41422-024-01051-x","DOIUrl":null,"url":null,"abstract":"<p><b>The beneficial role of gasdermin activation and pyroptosis induction in antitumor immunity has been implicated by several studies; however, the question of how to specifically and efficiently activate cancer cell death while minimizing toxicity to host cells remains unsolved. In a recent paper published in</b> <b><i>Cell</i></b><b>, Wu and Lieberman groups identified a GSDMD agonist that can induce low-level pyroptosis in cancer cells but not in host cells, offering potential applications in cancer vaccine development and therapy in combination with checkpoint blockade</b>.</p>","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":"41 1","pages":""},"PeriodicalIF":28.1000,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cell Research","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1038/s41422-024-01051-x","RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
The beneficial role of gasdermin activation and pyroptosis induction in antitumor immunity has been implicated by several studies; however, the question of how to specifically and efficiently activate cancer cell death while minimizing toxicity to host cells remains unsolved. In a recent paper published inCell, Wu and Lieberman groups identified a GSDMD agonist that can induce low-level pyroptosis in cancer cells but not in host cells, offering potential applications in cancer vaccine development and therapy in combination with checkpoint blockade.
期刊介绍：
Cell Research (CR) is an international journal published by Springer Nature in partnership with the Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences (CAS). It focuses on publishing original research articles and reviews in various areas of life sciences, particularly those related to molecular and cell biology. The journal covers a broad range of topics including cell growth, differentiation, and apoptosis; signal transduction; stem cell biology and development; chromatin, epigenetics, and transcription; RNA biology; structural and molecular biology; cancer biology and metabolism; immunity and molecular pathogenesis; molecular and cellular neuroscience; plant molecular and cell biology; and omics, system biology, and synthetic biology. CR is recognized as China's best international journal in life sciences and is part of Springer Nature's prestigious family of Molecular Cell Biology journals.
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