Sex differences of visceral fat with cardiac structure and function in type 2 diabetes: A cross-sectional study

IF 3 2区医学 Q2 ENDOCRINOLOGY & METABOLISM Journal of Diabetes Pub Date : 2024-11-07 DOI:10.1111/1753-0407.70023

Chen Rui-hua, Lin Yi, Xu Huan-bai, Wang Yu-fan, Peng Yong-de

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Abstract

Background

The aim of this study is to analyze the associations among fat distribution, left ventricular (LV) structure, and function in T2DM patients and further assess the sex differences among them.

Methods

Two thousand and one hundred seven T2DM patients were enrolled to this study. Patients' height, weight, BMI, visceral fat area (VFA), baPWV, parameters of cardiac structure and function, and clinical biochemical indicators were measured and collected.

Results

There were significant differences between male and female T2DM patients in age, duration of diabetes, complication ratio of hypertension and dyslipidemia, smoking history, visceral fat, baPWV, and ventricular structure and function (p < 0.05). Compared with the Q1 group, female patients in the highest quartile (Q4) of VFA had a decreased LVEF and significantly increased baPWV (p < 0.05), whereas no such changes were found in males. The correlation analysis showed that LVEF in male patients was negatively correlated with hypertension history, using of CCBs, GLP-1RA, lipid-lowering medications, BMI, WC, WHR, FPG, FC-P, HbA1c, GA, HOMA-IR, Cr, and baPWV, while the LVEF in female patients was negatively correlated with VFA, VSR, VFA/BMI, VFA/H², VFA/weight in females (p < 0.05). LVMI was positively associated with diabetes duration, age, hypertension history, WC, WHR, VFA, SFA, VFA/BMI, VFA/H², VFA/weight, and baPWV in both males and females. Multivariable-adjusted linear regression analysis showed that VFA was independently associated with LVEF (β = − 0.096, p = 0.010), LVMI (β = 0.083, p = 0.038), and baPWV (β = 0.120, p = 0.003) in females.

Conclusions

Values of VFA were independently associated with LVEF, LVMI, and baPWV in women, but not in men, in patients with T2DM.

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2型糖尿病患者内脏脂肪与心脏结构和功能的性别差异：一项横断面研究

背景：本研究旨在分析 T2DM 患者的脂肪分布、左心室结构和功能之间的关系，并进一步评估其性别差异：本研究旨在分析 T2DM 患者的脂肪分布、左心室（LV）结构和功能之间的关联，并进一步评估其中的性别差异：本研究共招募了 2 107 名 T2DM 患者。测量并收集患者的身高、体重、体重指数（BMI）、内脏脂肪面积（VFA）、baPWV、心脏结构和功能参数以及临床生化指标：男性和女性 T2DM 患者在年龄、糖尿病病程、高血压和血脂异常并发症比例、吸烟史、内脏脂肪、baPWV、心室结构和功能（p 2，女性的内脏脂肪面积/体重（p 2，男性和女性的内脏脂肪面积/体重、baPWV）方面均存在明显差异。多变量调整线性回归分析显示，VFA 与女性的 LVEF（β = - 0.096，p = 0.010）、LVMI（β = 0.083，p = 0.038）和 baPWV（β = 0.120，p = 0.003）独立相关：结论：在 T2DM 患者中，VFA 值与女性 LVEF、LVMI 和 baPWV 独立相关，但与男性无关。

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来源期刊

Journal of Diabetes ENDOCRINOLOGY & METABOLISM-

CiteScore

6.50

自引率

2.20%

发文量

审稿时长

>12 weeks

期刊介绍： Journal of Diabetes (JDB) devotes itself to diabetes research, therapeutics, and education. It aims to involve researchers and practitioners in a dialogue between East and West via all aspects of epidemiology, etiology, pathogenesis, management, complications and prevention of diabetes, including the molecular, biochemical, and physiological aspects of diabetes. The Editorial team is international with a unique mix of Asian and Western participation. The Editors welcome submissions in form of original research articles, images, novel case reports and correspondence, and will solicit reviews, point-counterpoint, commentaries, editorials, news highlights, and educational content.