CD1a affects the recurrence and prognosis of ovarian cancer

IF 1.6 4区医学 Q3 OBSTETRICS & GYNECOLOGY Journal of Obstetrics and Gynaecology Research Pub Date : 2024-11-07 DOI:10.1111/jog.16120

Qiong Zhu, Jun Liu, Yinghao Xie, Chengqiu Wu

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引用次数: 0

Abstract

Objective

Explored the correlation between CD1a expression in recurrence and prognosis of ovarian cancer (OV).

Methods

The CD1a expression profile in OV, recurrent OV, and normal tissues, as well as corresponding clinical data, were obtained from The Cancer Genome Atlas (TCGA), International Cancer Genome Consortium (ICGC), Gene Expression Omnibus (GEO), and Genotype Tissue Expression (GTEx) databases. Meanwhile, immunohistochemical detection of CD1a expression in normal and OV tissues. Kaplan–Meier curves were plotted to estimate the hazard ratio (HR) of survival in OV. In addition, the correlation between CD1a and immune cells in OV, as well as the CD1a expression profile and corresponding survival time in pan-cancer were obtained from TCGA database.

Results

CD1a was overexpressed in OV and was significantly under-expressed in recurrent OV (TCGA-OV, p < 0.0001 and ICGC-OV, p < 0.0001). CD1a immunohistochemistry is significantly overexpressed in OV compared to normal tissue (p < 0.05). Recurrent OV (ICGC, p < 0.001; GSE17260, p < 0.001; GSE32062, p < 0.05). The prognosis in OV was significantly better when CD1a is overexpressed compared to under-expressed (HR [low], 1.426: 95% confidence interval [CI], 0.912–2.128; p = 0.050). Meanwhile, the overexpression of CD1a has a better prognosis than low expression in OV and recurrent OV (p = 0.004, HR [low] = 2.462, 95%CI [1.346–4.504] and p = 0.011, HR [low] = 2.199, 95%CI [1.202–4.024]). In addition, CD1a expression was closely correlated with immune cells, the CD8+ T cells, macrophages, and NK cells, while uncharacterized cells were significantly different (p = 2.65e−6, p = 7.52e−13, p = 8.28e−12, and p = 5.89e−8, respectively). Moreover, CD1a expression affected the prognosis in various other cancers.

Conclusions

CD1a expression affected the recurrence and prognosis of OV and is closely related to various immune cell levels.

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CD1a 影响卵巢癌的复发和预后。

目的：探讨 CD1a 表达与卵巢癌（OV）复发和预后的相关性：探讨CD1a表达在卵巢癌（OV）复发和预后中的相关性：方法：从The Cancer Genome Atlas（TCGA）、International Cancer Genome Consortium（ICGC）、Gene Expression Omnibus（GEO）和Genotype Tissue Expression（GTEx）数据库中获取卵巢癌、复发性卵巢癌和正常组织中CD1a的表达谱以及相应的临床数据。同时，免疫组化检测CD1a在正常组织和OV组织中的表达。绘制 Kaplan-Meier 曲线以估算 OV 的生存危险比（HR）。此外，还从TCGA数据库中获得了OV中CD1a与免疫细胞的相关性，以及泛癌中CD1a的表达谱和相应的生存时间：结果：CD1a在OV中表达过高，在复发性OV中表达明显偏低（TCGA-OV，p 结论：CD1a的表达影响OV的复发率：CD1a的表达影响OV的复发和预后，并与各种免疫细胞水平密切相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Obstetrics and Gynaecology Research 医学-妇产科学

CiteScore

3.10

自引率

0.00%

发文量

376

审稿时长

3-6 weeks

期刊介绍： The Journal of Obstetrics and Gynaecology Research is the official Journal of the Asia and Oceania Federation of Obstetrics and Gynecology and of the Japan Society of Obstetrics and Gynecology, and aims to provide a medium for the publication of articles in the fields of obstetrics and gynecology. The Journal publishes original research articles, case reports, review articles and letters to the editor. The Journal will give publication priority to original research articles over case reports. Accepted papers become the exclusive licence of the Journal. Manuscripts are peer reviewed by at least two referees and/or Associate Editors expert in the field of the submitted paper.