Exploring the associations and potential mediators between lipid biomarkers and the risk of developing gout: NHANES 2007-2018.

IF 3.9 2区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Lipids in Health and Disease Pub Date : 2024-11-07 DOI:10.1186/s12944-024-02346-z

Yuzhe Huang, Ying Li, Zhounan Wu, Yuhang Liang, Jinshen He

{"title":"Exploring the associations and potential mediators between lipid biomarkers and the risk of developing gout: NHANES 2007-2018.","authors":"Yuzhe Huang, Ying Li, Zhounan Wu, Yuhang Liang, Jinshen He","doi":"10.1186/s12944-024-02346-z","DOIUrl":null,"url":null,"abstract":"Background: Gout stands as a prevailing manifestation of inflammatory arthritis. While it is linked to several well-established risk factors, the associations between lipid profiles and the risk of gout remain unclear.Methods: This research involved National Health and Nutrition Examination Survey data (2007-2018). The cardiometabolic index, which incorporates the Triglycerides (TG)/High-density lipoprotein cholesterol (HDL) ratio and waist to height ratio (WHtR), was used to assess lipid profiles and metabolic health. Multivariate logistic regression analysis, propensity score matching, and mediation analyses were utilized to evaluate the associations of lipid profiles and the cardiometabolic index with the risk of developing gout.Results: Among 11,032 participants, each 1-unit increase in TG levels was associated with a 65% increase in the odds of developing gout before matching [1.65 (1.15-2.38), P = 0.007] and a 155% increase in the odds of developing gout after matching [2.55 (1.59-4.09), P = 0.007]. Each 1-unit increase in the cardiometabolic index was linked to an 81% increase in the odds of developing gout before matching [1.81 (1.22-2.70), P = 0.004] and a 215% increase in the odds of developing gout after matching [3.15 (1.84-5.40), P < 0.001]. The participants with HDL levels in the third quartile presented a 35% reduction in gout risk relative to those with HDL levels in the first quartile before matching [0.65 (0.46-0.92), P = 0.014] and a 51% reduction in gout risk after matching [0.49 (0.32-0.75), P < 0.001]. Mediation analyses revealed that BMI, WHtR, and homeostatic model assessment for insulin resistance (HOMA-IR) mediated the relationships between TG levels and the risk of developing gout at 18.75%, 24.28%, and 5.35%, respectively. For the association between HDL levels and the risk of developing gout, the mediating effects of BMI, WHtR, leukocytes, γ-glutamyltransferase (in those with HDL < 56 mmol/L), and HOMA-IR were 57.98%, 69.03%, 8.77%, 5.18%, and 11.14%, respectively.Conclusion: This study reveals the relationship between lipid profiles and the risk of developing gout. Regularly checking TG and HDL levels and actively managing obesity, insulin resistance, oxidative stress and inflammation are important for lowering the risk of developing gout.","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"23 1","pages":"363"},"PeriodicalIF":3.9000,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11542235/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Lipids in Health and Disease","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s12944-024-02346-z","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Gout stands as a prevailing manifestation of inflammatory arthritis. While it is linked to several well-established risk factors, the associations between lipid profiles and the risk of gout remain unclear.

Methods: This research involved National Health and Nutrition Examination Survey data (2007-2018). The cardiometabolic index, which incorporates the Triglycerides (TG)/High-density lipoprotein cholesterol (HDL) ratio and waist to height ratio (WHtR), was used to assess lipid profiles and metabolic health. Multivariate logistic regression analysis, propensity score matching, and mediation analyses were utilized to evaluate the associations of lipid profiles and the cardiometabolic index with the risk of developing gout.

Results: Among 11,032 participants, each 1-unit increase in TG levels was associated with a 65% increase in the odds of developing gout before matching [1.65 (1.15-2.38), P = 0.007] and a 155% increase in the odds of developing gout after matching [2.55 (1.59-4.09), P = 0.007]. Each 1-unit increase in the cardiometabolic index was linked to an 81% increase in the odds of developing gout before matching [1.81 (1.22-2.70), P = 0.004] and a 215% increase in the odds of developing gout after matching [3.15 (1.84-5.40), P < 0.001]. The participants with HDL levels in the third quartile presented a 35% reduction in gout risk relative to those with HDL levels in the first quartile before matching [0.65 (0.46-0.92), P = 0.014] and a 51% reduction in gout risk after matching [0.49 (0.32-0.75), P < 0.001]. Mediation analyses revealed that BMI, WHtR, and homeostatic model assessment for insulin resistance (HOMA-IR) mediated the relationships between TG levels and the risk of developing gout at 18.75%, 24.28%, and 5.35%, respectively. For the association between HDL levels and the risk of developing gout, the mediating effects of BMI, WHtR, leukocytes, γ-glutamyltransferase (in those with HDL < 56 mmol/L), and HOMA-IR were 57.98%, 69.03%, 8.77%, 5.18%, and 11.14%, respectively.

Conclusion: This study reveals the relationship between lipid profiles and the risk of developing gout. Regularly checking TG and HDL levels and actively managing obesity, insulin resistance, oxidative stress and inflammation are important for lowering the risk of developing gout.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

探索血脂生物标志物与痛风发病风险之间的关联和潜在中介因素Nhanes 2007-2018。

背景：痛风是炎症性关节炎的一种主要表现形式。虽然痛风与几种公认的风险因素有关，但血脂状况与痛风风险之间的关系仍不清楚：本研究涉及美国国家健康与营养调查数据（2007-2018 年）。心血管代谢指数包括甘油三酯（TG）/高密度脂蛋白胆固醇（HDL）比率和腰围与身高比率（WHtR），用于评估血脂状况和代谢健康。利用多变量逻辑回归分析、倾向得分匹配和中介分析来评估血脂状况和心脏代谢指数与痛风发病风险的关系：在 11,032 名参与者中，匹配前 TG 水平每增加 1 个单位，痛风发病几率增加 65% [1.65 (1.15-2.38)，P = 0.007]，匹配后痛风发病几率增加 155% [2.55 (1.59-4.09)，P = 0.007]。心血管代谢指数每增加 1 个单位，配对前患痛风的几率增加 81%[1.81 (1.22-2.70)，P = 0.004]，配对后患痛风的几率增加 215%[3.15 (1.84-5.40)，P 结论：本研究揭示了血脂状况与痛风发病风险之间的关系。定期检查总胆固醇和高密度脂蛋白水平，积极控制肥胖、胰岛素抵抗、氧化应激和炎症对降低痛风发病风险非常重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Lipids in Health and Disease 生物-生化与分子生物学

CiteScore

7.70

自引率

2.20%

发文量

122

审稿时长

3-8 weeks

期刊介绍： Lipids in Health and Disease is an open access, peer-reviewed, journal that publishes articles on all aspects of lipids: their biochemistry, pharmacology, toxicology, role in health and disease, and the synthesis of new lipid compounds. Lipids in Health and Disease is aimed at all scientists, health professionals and physicians interested in the area of lipids. Lipids are defined here in their broadest sense, to include: cholesterol, essential fatty acids, saturated fatty acids, phospholipids, inositol lipids, second messenger lipids, enzymes and synthetic machinery that is involved in the metabolism of various lipids in the cells and tissues, and also various aspects of lipid transport, etc. In addition, the journal also publishes research that investigates and defines the role of lipids in various physiological processes, pathology and disease. In particular, the journal aims to bridge the gap between the bench and the clinic by publishing articles that are particularly relevant to human diseases and the role of lipids in the management of various diseases.