Engineered Macrophage Exosomes Deliver Drug-Targeted Therapy for Breast Cancer.

Mingrui Feng, Lifang Zhang, Zhuoling Zou, Mengying Xie, Jianbo Zhang, Jiayang Wang, Keqin Wang, Jun Zhu, Lixia Xiong
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Abstract

Breast cancer is a highly widespread form of malignant tumor characterized by a high rate of recurrence and mortality; it primarily occurs when tumor cells spread to peripheral regions of the body. Macrophages have a significant impact on the proliferation and metastasis of breast cancer. The exosomes generated by these cells exhibit an extensive spectrum of capabilities in suppressing the spread of cancer cells. These feature very specific targeting properties for breast cancer cells and inhibit the proliferation of cancer cells by altering the immune milieu within the tumor. This study investigates methods for developing macrophage-derived exosomes, such as using protein-coupled exosome membranes to protect delivery contents, creating multifunctional biomimetic particles, and utilizing ultrasonic fusion to protect delivery contents. Furthermore, this paper addresses recent advances in producing macrophage exosomes from organic and inorganic materials. In general, targeted treatment for breast cancer could benefit greatly from creating drug delivery systems mediated by macrophage exosomes.

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工程化巨噬细胞外泌体为乳腺癌提供药物靶向疗法
乳腺癌是一种高度广泛的恶性肿瘤,其特点是复发率和死亡率高;它主要发生在肿瘤细胞扩散到身体外周区域的时候。巨噬细胞对乳腺癌的扩散和转移有重要影响。这些细胞产生的外泌体在抑制癌细胞扩散方面具有广泛的功能。这些外泌体对乳腺癌细胞具有非常特异的靶向性,并通过改变肿瘤内的免疫环境来抑制癌细胞的增殖。本研究探讨了开发巨噬细胞外泌体的方法,如使用蛋白偶联外泌体膜保护输送内容物、创建多功能生物仿生颗粒以及利用超声波融合保护输送内容物。此外,本文还介绍了利用有机和无机材料生产巨噬细胞外泌体的最新进展。总之,通过创建由巨噬细胞外泌体介导的药物递送系统,乳腺癌的靶向治疗将受益匪浅。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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