Early Onset Colorectal Cancer: Molecular Underpinnings Accelerating Occurrence.

IF 7.1 1区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Cellular and Molecular Gastroenterology and Hepatology Pub Date : 2025-01-01 Epub Date: 2024-11-05 DOI:10.1016/j.jcmgh.2024.101425

Atehkeng Zinkeng, F Lloyd Taylor, Samuel H Cheong, Heyu Song, Juanita L Merchant

引用次数: 0

Abstract

The onset of colorectal cancer (CRC) in patients younger than 50 continues to rapidly increase. This study highlights the epidemiologic changes, risk factors, clinical characteristics, and molecular profiles prevalent in early onset CRC patients, and identifies key areas for future research. It has been noted that only a small fraction of early onset CRC cases is attributed to known hereditary mutations and fit the canonical pathway of late-onset colorectal cancer development. To highlight this, we review the genetic and epigenetic modifications specific to early onset CRC. We also discuss the synergetic effect of single-nucleotide polymorphisms and environmental factors on the early onset of CRC. Additionally, we discuss the potential of noninvasive biomarker assays to enhance early detection, screening, diagnosis, and prognostic outcome predictions.

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早发结直肠癌：加速发病的分子基础。

50 岁以下患者罹患结直肠癌（CRC）的人数持续快速增长。本研究强调了早发结直肠癌（EO-CRC）患者的流行病学变化、风险因素、临床特征和分子特征，并确定了未来研究的关键领域。人们注意到，EO-CRC 病例中只有一小部分归因于已知的遗传突变，并符合晚发结直肠癌（LOCRC）的典型发展途径。为了强调这一点，我们回顾了 EO-CRC 特有的遗传和表观遗传修饰。我们还讨论了单核苷酸多态性（SNPs）和环境因素对 CRC 早期发病的协同作用。此外，我们还讨论了非侵入性生物标志物检测在加强早期检测、筛查、诊断和预后结果预测方面的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cellular and Molecular Gastroenterology and Hepatology Medicine-Gastroenterology

CiteScore

13.00

自引率

2.80%

发文量

246

审稿时长

42 days

期刊介绍： "Cell and Molecular Gastroenterology and Hepatology (CMGH)" is a journal dedicated to advancing the understanding of digestive biology through impactful research that spans the spectrum of normal gastrointestinal, hepatic, and pancreatic functions, as well as their pathologies. The journal's mission is to publish high-quality, hypothesis-driven studies that offer mechanistic novelty and are methodologically robust, covering a wide range of themes in gastroenterology, hepatology, and pancreatology. CMGH reports on the latest scientific advances in cell biology, immunology, physiology, microbiology, genetics, and neurobiology related to gastrointestinal, hepatobiliary, and pancreatic health and disease. The research published in CMGH is designed to address significant questions in the field, utilizing a variety of experimental approaches, including in vitro models, patient-derived tissues or cells, and animal models. This multifaceted approach enables the journal to contribute to both fundamental discoveries and their translation into clinical applications, ultimately aiming to improve patient care and treatment outcomes in digestive health.