Atehkeng Zinkeng, F Lloyd Taylor, Samuel H Cheong, Heyu Song, Juanita L Merchant
{"title":"Early-Onset Colorectal Cancer: Molecular Underpinnings Accelerating Occurrence.","authors":"Atehkeng Zinkeng, F Lloyd Taylor, Samuel H Cheong, Heyu Song, Juanita L Merchant","doi":"10.1016/j.jcmgh.2024.101425","DOIUrl":null,"url":null,"abstract":"<p><p>The onset of colorectal cancer (CRC) in patients under 50 continues to rapidly increase. This study highlights the epidemiological changes, risk factors, clinical characteristics, and molecular profiles prevalent in early-onset colorectal cancer (EO-CRC) patients, and identifies key areas for future research. It has been noted that only a small fraction of EO-CRC cases is attributed to known hereditary mutations and fit the canonical pathway of late onset colorectal cancer (LOCRC) development. To highlight this, we review the genetic and epigenetic modifications specific to EO-CRC. We also discuss the synergetic effect of single nucleotide polymorphisms (SNPs) and environmental factors on the early onset of CRC. Additionally, we discuss the potential of non-invasive biomarker assays to enhance early detection, screening, diagnosis, and prognostic outcome predictions.</p>","PeriodicalId":55974,"journal":{"name":"Cellular and Molecular Gastroenterology and Hepatology","volume":" ","pages":"101425"},"PeriodicalIF":7.1000,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cellular and Molecular Gastroenterology and Hepatology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.jcmgh.2024.101425","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"GASTROENTEROLOGY & HEPATOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
The onset of colorectal cancer (CRC) in patients under 50 continues to rapidly increase. This study highlights the epidemiological changes, risk factors, clinical characteristics, and molecular profiles prevalent in early-onset colorectal cancer (EO-CRC) patients, and identifies key areas for future research. It has been noted that only a small fraction of EO-CRC cases is attributed to known hereditary mutations and fit the canonical pathway of late onset colorectal cancer (LOCRC) development. To highlight this, we review the genetic and epigenetic modifications specific to EO-CRC. We also discuss the synergetic effect of single nucleotide polymorphisms (SNPs) and environmental factors on the early onset of CRC. Additionally, we discuss the potential of non-invasive biomarker assays to enhance early detection, screening, diagnosis, and prognostic outcome predictions.
期刊介绍：
"Cell and Molecular Gastroenterology and Hepatology (CMGH)" is a journal dedicated to advancing the understanding of digestive biology through impactful research that spans the spectrum of normal gastrointestinal, hepatic, and pancreatic functions, as well as their pathologies. The journal's mission is to publish high-quality, hypothesis-driven studies that offer mechanistic novelty and are methodologically robust, covering a wide range of themes in gastroenterology, hepatology, and pancreatology.
CMGH reports on the latest scientific advances in cell biology, immunology, physiology, microbiology, genetics, and neurobiology related to gastrointestinal, hepatobiliary, and pancreatic health and disease. The research published in CMGH is designed to address significant questions in the field, utilizing a variety of experimental approaches, including in vitro models, patient-derived tissues or cells, and animal models. This multifaceted approach enables the journal to contribute to both fundamental discoveries and their translation into clinical applications, ultimately aiming to improve patient care and treatment outcomes in digestive health.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
