Daniel O'Reilly, Charlotte Jones, Aisling Smith, David Mackin, Laura Mc Donald, John Quinn, Maeve O'Reilly, Aisling M Flinn, Ronan Leahy, David Williams, Jennifer Donnelly, David Corcoran
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引用次数: 0
Abstract
Introduction: Chimeric antigen receptor T cells (CAR-Ts) targeting CD19 represent a significant advance in treatment for patients with relapsed/refractory B-cell malignancies. Although a significant minority of recipients are women during their reproductive years, there is a paucity of data regarding pregnancy and neonatal outcomes in women previously treated with CAR-T. This is important as maternal T cells are known to cross the placenta and into breastmilk during pregnancy and breastfeeding, respectively.
Case presentation: Here we present two successful pregnancies following CAR-T therapy where both neonates were initially breastfed. These represent the first cases of neonates born following CAR-T therapy comprehensively described in medical literature.
Conclusion: Pregnancy following CAR-T therapy does not appear to be associated with adverse neonatal outcomes. Further work is required to delineate the outcomes in this population.
简介以 CD19 为靶点的嵌合抗原受体 T 细胞（CAR-T）是治疗复发/难治性 B 细胞恶性肿瘤患者的一大进步。虽然有相当一部分接受者是育龄期妇女，但有关曾接受过 CAR-T 治疗的妇女的妊娠和新生儿预后的数据却很少。这一点非常重要，因为众所周知，母体 T 细胞会在妊娠和哺乳期间分别穿过胎盘和进入母乳：在此，我们介绍了两例在接受 CAR-T 治疗后成功怀孕的病例，这两例病例的新生儿最初都是母乳喂养。这些病例是医学文献中全面描述的第一例接受 CAR-T 疗法后出生的新生儿：结论：CAR-T疗法后妊娠似乎与新生儿不良结局无关。结论：CAR-T疗法后妊娠似乎与新生儿的不良预后无关。
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