Human Circovirus in Patients with Hepatitis, Hong Kong

IF 7.2 2区医学 Q1 IMMUNOLOGY Emerging Infectious Diseases Pub Date : 2024-11-13 DOI:10.3201/eid3012.241114

Shusheng Wu, Cyril Chik-Yan Yip, Jianwen Situ, Zhiyu Li, Stanley Siu-Fung Ho, Jianpiao Cai, Jane Hau-Ching Poon, Nicholas Foo-Siong Chew, Jonathan Daniel Ip, Tom Wai-Hin Chung, Kelvin Hei-Yeung Chiu, Anna Jinxia Zhang, Estie Hon-Kiu Shun, James Yiu-Hung Tsoi, Jade Lee-Lee Teng, David Christopher Lung, Kelvin Kai-Wang To, Vincent Chi-Chung Cheng, Irene Oi-Lin Ng, Kwok-Yung Yuen, Siddharth Sridhar

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Abstract

Circovirus human is a new viral species that includes the human circovirus (HCirV), which has been linked to hepatitis in immunocompromised persons. We investigated prevalence of HCirV infection in 278 patients with hepatitis and 184 asymptomatic persons using real-time PCR and sequencing assays. HCirV viremia and sequences were found in 8 (2.9%) hepatitis patients and no asymptomatic patients. Alternate causes of hepatitis (hepatitis E and cholangitis) were clearly identifiable in 2 HCirV-infected patients. HCirV could not be ruled out as a contributor to hepatitis in the remaining 6 patients, 4 of whom were immunocompromised. Persistent infections were documented in 3 patients, but only 1 had relapsing hepatitis. One HCirV patient displayed symptoms of an infectious mononucleosis-like syndrome. Isolates clustered with known HCirV strains from France and China. HCirV-derived virus-like particles bound to PLC/PRF/5 and Hep-G2 human hepatoma cells but not to lung epithelial cells, indicating hepatic tropism.

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香港肝炎患者的人类循环病毒

人类圆环病毒是一种新病毒，包括人类圆环病毒（HCirV），它与免疫力低下者的肝炎有关。我们使用实时 PCR 和测序方法调查了 278 名肝炎患者和 184 名无症状者的 HCirV 感染率。在 8 名肝炎患者（2.9%）和无症状患者中发现了 HCirV 病毒血症和序列。在 2 名感染 HCirV 的患者中，可以明确确定肝炎的其他病因（戊型肝炎和胆管炎）。其余 6 名患者的肝炎病因无法排除 HCirV，其中 4 人免疫力低下。有 3 名患者出现持续感染，但只有 1 名患者出现复发性肝炎。一名 HCirV 患者表现出传染性单核细胞增多症样综合征的症状。分离物与来自法国和中国的已知 HCirV 株系聚集在一起。HCirV 衍生的病毒样颗粒与 PLC/PRF/5 和 Hep-G2 人肝癌细胞结合，但不与肺上皮细胞结合，这表明它具有肝趋向性。

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来源期刊

Emerging Infectious Diseases 医学-传染病学

CiteScore

17.30

自引率

1.70%

发文量

505

审稿时长

1 months

期刊介绍： Emerging Infectious Diseases is a monthly open access journal published by the Centers for Disease Control and Prevention. The primary goal of this peer-reviewed journal is to advance the global recognition of both new and reemerging infectious diseases, while also enhancing our understanding of the underlying factors that contribute to disease emergence, prevention, and elimination. Targeted towards professionals in the field of infectious diseases and related sciences, the journal encourages diverse contributions from experts in academic research, industry, clinical practice, public health, as well as specialists in economics, social sciences, and other relevant disciplines. By fostering a collaborative approach, Emerging Infectious Diseases aims to facilitate interdisciplinary dialogue and address the multifaceted challenges posed by infectious diseases.