Advances in the application of carbon dots-based fluorescent probes in disease biomarker detection.

IF 5.4 2区医学 Q1 BIOPHYSICS Colloids and Surfaces B: Biointerfaces Pub Date : 2024-11-05 DOI:10.1016/j.colsurfb.2024.114360

Haoqi Zhang, Qingmei Zhang, Naihui Li, Guoqing Yang, Zewei Cheng, Xiujuan Du, Lingxiang Sun, Wei Wang, Bing Li

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Abstract

Carbon dots (CDs), as an emerging nanomaterial, have shown tremendous potential in disease biomarker detection. CDs can selectively interact with different target molecules, enabling highly sensitive and specific detection of these biomolecules. Compared to traditional detection methods, CDs sensors offer advantages such as rapid response, high detection sensitivity, and low cost. In this review, we summarize the latest advances in the application of CDs fluorescence probes for the detection of disease biomarkers, including sensing mechanisms, and their applications in the selective detection of metal ions, amino acids, enzymes, proteins, other biomolecules, as well as bacteria and viruses. We discuss the current challenges and issues associated with the practical application of CDs-based fluorescent probes. Furthermore, we propose future directions for the development of CDs. We hope that this review will provide new insights for researchers in the field of disease biomarker detection.

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碳点荧光探针在疾病生物标记物检测中的应用进展。

碳点（CD）作为一种新兴的纳米材料，在疾病生物标记物检测方面显示出巨大的潜力。碳点可以选择性地与不同的目标分子相互作用，从而实现对这些生物分子的高灵敏度和特异性检测。与传统检测方法相比，光盘传感器具有反应迅速、检测灵敏度高、成本低等优点。在这篇综述中，我们总结了应用 CDs 荧光探针检测疾病生物标志物的最新进展，包括传感机制及其在选择性检测金属离子、氨基酸、酶、蛋白质、其他生物大分子以及细菌和病毒中的应用。我们讨论了当前与基于 CD 的荧光探针的实际应用相关的挑战和问题。此外，我们还提出了 CD 的未来发展方向。我们希望这篇综述能为疾病生物标记物检测领域的研究人员提供新的见解。

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来源期刊

Colloids and Surfaces B: Biointerfaces 生物-材料科学：生物材料

CiteScore

11.10

自引率

3.40%

发文量

730

审稿时长

42 days

期刊介绍： Colloids and Surfaces B: Biointerfaces is an international journal devoted to fundamental and applied research on colloid and interfacial phenomena in relation to systems of biological origin, having particular relevance to the medical, pharmaceutical, biotechnological, food and cosmetic fields. Submissions that: (1) deal solely with biological phenomena and do not describe the physico-chemical or colloid-chemical background and/or mechanism of the phenomena, and (2) deal solely with colloid/interfacial phenomena and do not have appropriate biological content or relevance, are outside the scope of the journal and will not be considered for publication. The journal publishes regular research papers, reviews, short communications and invited perspective articles, called BioInterface Perspectives. The BioInterface Perspective provide researchers the opportunity to review their own work, as well as provide insight into the work of others that inspired and influenced the author. Regular articles should have a maximum total length of 6,000 words. In addition, a (combined) maximum of 8 normal-sized figures and/or tables is allowed (so for instance 3 tables and 5 figures). For multiple-panel figures each set of two panels equates to one figure. Short communications should not exceed half of the above. It is required to give on the article cover page a short statistical summary of the article listing the total number of words and tables/figures.