Changes in Erythrocytes in 88 Hyperthyroid Cats.

IF 2.7 2区农林科学 Q1 AGRICULTURE, DAIRY & ANIMAL SCIENCE Animals Pub Date : 2024-10-31 DOI:10.3390/ani14213136

Olga Gójska-Zygner, Grzegorz Kotomski, Joanna Gajger, Luke J Norbury, Wojciech Zygner

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Abstract

Background: There is only a limited number of studies that show alterations in erythrocytes in feline hyperthyroidism. Discrepancies between the findings of these studies may be caused by the presence of concurrent diseases and the use of various haematological analysers.

Methods: This study analysed changes in red blood cells (RBCs) in 88 hyperthyroid cats without concurrent diseases, to identify associations between observed changes and to assess the influence of serum thyroxine (T4) concentration, cat age, and sex, on RBC changes.

Results: Among the eighty-eight hyperthyroid cats, erythrocytosis was observed in twelve, anaemia in four, macrocytosis in two, and microcytosis in three. Three of the four cases of anaemia probably resulted from concurrent unrecognised disease. Interestingly, all cases of microcytosis were recognized in cats that had erythrocytosis. This study identified a moderate negative correlation between RBC count and mean corpuscular volume (MCV; r = -0.57, p < 0.001). Concluding, it appears that erythrocytosis may be a response to the development of microcytosis. The correlation between RBC count and MCV in hyperthyroid cats may result from the increased action of hepcidin and erythropoietin coupled with the decreased action of thyroid-stimulating hormone (TSH).

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88 只甲亢猫红细胞的变化

背景：只有数量有限的研究显示猫甲状腺机能亢进症患者的红细胞发生了变化。这些研究结果之间的差异可能是由于并发疾病的存在和使用不同的血液分析仪造成的：本研究分析了88只无并发疾病的甲亢猫的红细胞（RBC）变化，以确定观察到的变化之间的关联，并评估血清甲状腺素（T4）浓度、猫的年龄和性别对红细胞变化的影响：结果：在 88 只甲亢猫中，有 12 只出现红细胞增多症，4 只出现贫血，2 只出现大红细胞增多症，3 只出现小红细胞增多症。四例贫血中的三例可能是由于同时患有未被发现的疾病所致。有趣的是，所有小红细胞症病例都是在患有红细胞增多症的猫中发现的。这项研究发现，红细胞计数与平均血红蛋白量（MCV）之间存在中度负相关；r = -0.57，p < 0.001。总之，红细胞增多症似乎是对小红细胞增多症发展的一种反应。甲亢猫的红细胞计数和 MCV 之间的相关性可能是由于促红细胞生成素和促红细胞生成素的作用增强，而促甲状腺激素（TSH）的作用减弱。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Animals Agricultural and Biological Sciences-Animal Science and Zoology

CiteScore

4.90

自引率

16.70%

发文量

3015

审稿时长

20.52 days

期刊介绍： Animals (ISSN 2076-2615) is an international and interdisciplinary scholarly open access journal. It publishes original research articles, reviews, communications, and short notes that are relevant to any field of study that involves animals, including zoology, ethnozoology, animal science, animal ethics and animal welfare. However, preference will be given to those articles that provide an understanding of animals within a larger context (i.e., the animals'' interactions with the outside world, including humans). There is no restriction on the length of the papers. Our aim is to encourage scientists to publish their experimental and theoretical research in as much detail as possible. Full experimental details and/or method of study, must be provided for research articles. Articles submitted that involve subjecting animals to unnecessary pain or suffering will not be accepted, and all articles must be submitted with the necessary ethical approval (please refer to the Ethical Guidelines for more information).