A case of T-cell large granular lymphocytic leukemia with autoimmune hemolytic anemia and literature review.

Abstract

T-cell large granular lymphocyte leukemia (T-LGLL), which is associated with autoimmune diseases, has been described. However, T-LGLL with B-cell dyscrasias presenting as autoimmune hemolytic anemia has been less frequently reported. Here, we report a rare case of combined papillary thyroid cancer (PTC), discuss the possible relationship between autoimmune hemolytic anemia (AIHA) and TLGLL, and review the literature. The patient presented with pancytopenia and systemic jaundice. Fortunately, the patient responded well to hormone and immunosuppressive (methotrexate) therapy. However, this insight is based on one rare case, and the pathogenesis of this disease requires further clinical research for clarification.