Noncanonical Amino Acid Incorporation in Animals and Animal Cells.

IF 51.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Chemical Reviews Pub Date : 2024-11-14 DOI:10.1021/acs.chemrev.3c00955
Joo-Chan Kim, YouJin Kim, Suho Cho, Hee-Sung Park
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Abstract

Noncanonical amino acids (ncAAs) are synthetic building blocks that, when incorporated into proteins, confer novel functions and enable precise control over biological processes. These small yet powerful tools offer unprecedented opportunities to investigate and manipulate various complex life forms. In particular, ncAA incorporation technology has garnered significant attention in the study of animals and their constituent cells, which serve as invaluable model organisms for gaining insights into human physiology, genetics, and diseases. This review will provide a comprehensive discussion on the applications of ncAA incorporation technology in animals and animal cells, covering past achievements, current developments, and future perspectives.

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动物和动物细胞中的非顺式氨基酸结合
非典型氨基酸(ncAAs)是一种人工合成的构件,当被加入蛋白质中时,可赋予新的功能并实现对生物过程的精确控制。这些小而强大的工具为研究和操纵各种复杂的生命形式提供了前所未有的机会。特别是,ncAA 植入技术在动物及其组成细胞的研究中备受关注,而动物及其组成细胞是了解人类生理学、遗传学和疾病的宝贵模式生物。本综述将全面讨论 ncAA 植入技术在动物和动物细胞中的应用,包括过去的成就、当前的发展和未来的展望。
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来源期刊
Chemical Reviews
Chemical Reviews 化学-化学综合
CiteScore
106.00
自引率
1.10%
发文量
278
审稿时长
4.3 months
期刊介绍: Chemical Reviews is a highly regarded and highest-ranked journal covering the general topic of chemistry. Its mission is to provide comprehensive, authoritative, critical, and readable reviews of important recent research in organic, inorganic, physical, analytical, theoretical, and biological chemistry. Since 1985, Chemical Reviews has also published periodic thematic issues that focus on a single theme or direction of emerging research.
期刊最新文献
The Analysis of Electron Densities: From Basics to Emergent Applications Tackling Undruggable Targets with Designer Peptidomimetics and Synthetic Biologics Noncanonical Amino Acid Incorporation in Animals and Animal Cells. Issue Editorial Masthead Issue Publication Information
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