Advances in microneedles for delivery of active ingredients of natural herbals.

IF 1.6 4区 医学 Q4 BIOPHYSICS Biointerphases Pub Date : 2022-11-01 DOI:10.1116/6.0004073
Lin Fan, Jiang Sun, Dawei He
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Abstract

The active ingredients of natural herbs have been extracted to act on different targets in the body to exert multiple effects. However, traditional oral administration and intravenous injection of herbal medicines are also susceptible to many side effects. Transdermal drug delivery by microneedles can overcome the shortcomings of these traditional drug delivery systems. The active ingredients of natural herbs can be delivered to the dermis or the connective tissue layer by five types of microneedles: solid, hollow, coated, dissolving, and hydrogel. Subsequently, the herbal ingredients are delivered to different target points of the body through body circulation to exert their effects. In this study, we classified the microneedles that can deliver the active ingredients of natural herbs and summarized their advantages and disadvantages as well as their preparation methods and applications, to guide the development and clinical applications of other herbal transdermal microneedles.

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用于输送天然草药活性成分的微针技术进展。
天然草药的有效成分被提取出来,作用于人体内的不同靶点,发挥多重功效。然而,传统的口服和静脉注射中草药也容易产生许多副作用。微针透皮给药可以克服这些传统给药系统的缺点。天然草药的有效成分可通过五种类型的微针输送到真皮层或结缔组织层:实心微针、空心微针、涂层微针、溶解微针和水凝胶微针。随后,草药成分通过体循环被输送到身体的不同靶点,从而发挥其功效。本研究对可递送天然中草药有效成分的微针进行了分类,并总结了其优缺点、制备方法和应用,以指导其他中草药透皮微针的开发和临床应用。
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Biointerphases
Biointerphases 生物-材料科学:生物材料
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发文量
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期刊介绍: Biointerphases emphasizes quantitative characterization of biomaterials and biological interfaces. As an interdisciplinary journal, a strong foundation of chemistry, physics, biology, engineering, theory, and/or modelling is incorporated into originated articles, reviews, and opinionated essays. In addition to regular submissions, the journal regularly features In Focus sections, targeted on specific topics and edited by experts in the field. Biointerphases is an international journal with excellence in scientific peer-review. Biointerphases is indexed in PubMed and the Science Citation Index (Clarivate Analytics). Accepted papers appear online immediately after proof processing and are uploaded to key citation sources daily. The journal is based on a mixed subscription and open-access model: Typically, authors can publish without any page charges but if the authors wish to publish open access, they can do so for a modest fee. Topics include: bio-surface modification nano-bio interface protein-surface interactions cell-surface interactions in vivo and in vitro systems biofilms / biofouling biosensors / biodiagnostics bio on a chip coatings interface spectroscopy biotribology / biorheology molecular recognition ambient diagnostic methods interface modelling adhesion phenomena.
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