Idiothetic representations are modulated by availability of sensory inputs and task demands in the hippocampal-septal circuit.

Abstract

The hippocampus is a higher-order brain structure responsible for encoding new episodic memories and predicting future outcomes. In the absence of external stimuli, neurons in the hippocampus track elapsed time, distance traveled, and other idiothetic variables. To this day, the exact determinants of idiothetic representations during free navigation remain unclear. Here, we developed unsupervised approaches to extract population and single-cell properties of more than 30,000 CA1 pyramidal neurons in freely moving mice. We find that spatiotemporal representations are composed of a mixture of idiothetic and allocentric information, the balance of which is dictated by task demand and environmental conditions. Additionally, a subset of CA1 pyramidal neurons encodes the spatiotemporal distance to rewards. Finally, distance and time information is integrated postsynaptically in the lateral septum, indicating that these high-level representations are effectively integrated in downstream neurons.