Influence of mindfulness meditation on intracranial EEG parameters in epileptic and non-epileptic brain areas

IF 2.3 3区医学 Q2 BEHAVIORAL SCIENCES Epilepsy & Behavior Pub Date : 2024-11-13 DOI:10.1016/j.yebeh.2024.110150

Daniel D. Cummins , Zac Schulman , Christina Maher , Lea Tortolero , Adam Saad , Lizabeth Nunez Martinez , Richard J. Davidson , Lara V. Marcuse , Ignacio Saez , Fedor Panov

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Abstract

Objective

Mind-wandering is a pervasive human brain state and, when in excess, may promote negative affect and neuropsychiatric conditions. Mindfulness meditation may promote alternate brain states, improving affect and reducing stress. An understanding of the neural basis between these brain states could thus advance treatment of neuropsychiatric conditions, including those associated with epilepsy.

Methods

To explore the neural basis of mindfulness meditation versus mind-wandering, we enrolled eight patients in a trial of structured mindfulness meditation and open mind-wandering who underwent stereo electroencephalography (sEEG) within the mesial temporal lobe for seizure localization. Electrophysiology was compared between mind-wandering and mindfulness separately for epileptic and non-epileptic MTL. Using fitting-one-over-f modeling, periodic components of electrophysiology were compared in canonical frequency bands of theta (4–8 Hz), alpha (8–13 Hz), beta (13–30 Hz), and gamma (30–55 Hz). Aperiodic components of the power spectra were assessed by the model offset, knee, and exponent.

Results

We found a significant reduction in gamma power (30–55 Hz) within the mesial temporal lobe (MTL) during mindfulness meditation compared with mind-wandering in non-epileptic (p = 1.20E-4) but not in epileptic MTL (p = 0.352).There was also a significant difference between epileptic versus non-epileptic MTL in gamma power between conditions (p = 0.011). There were no significant changes in power across any frequency band within epileptic mesial temporal MTL between brain states. Conversely, there were significant differences between mind-wandering and mindfulness within epileptic MTL in aperiodic components (offset, knee, and exponent, all p < 0.05), while no differences in aperiodic components were seen in non-epileptic MTL (all p > 0.70).

Significance

Intracranial electrophysiologic modulations between brain state (mind-wandering versus mindfulness) may differ between epileptic and non-epileptic MTL. Modulations in gamma activity in non-epileptic MTL may represent functional changes in brain state, while aperiodic changes in epileptic MTL may modulate propensity for seizures.

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正念冥想对癫痫和非癫痫脑区颅内脑电图参数的影响。

目的：思维游离是一种普遍存在的人脑状态，过度游离可能导致负面情绪和神经精神疾病。正念冥想可以促进大脑状态的交替，改善情绪和减轻压力。因此，了解这些大脑状态之间的神经基础可以促进神经精神疾病的治疗，包括与癫痫相关的疾病：为了探索正念冥想与意念游走的神经基础，我们招募了八名患者参加结构化正念冥想和开放式意念游走试验，这些患者在颞叶中上部接受了立体脑电图（sEEG）检查，以确定癫痫发作位置。分别对癫痫性和非癫痫性 MTL 的意念游走和意念冥想的电生理学进行了比较。通过拟合一过一模型，比较了θ（4-8赫兹）、α（8-13赫兹）、β（13-30赫兹）和γ（30-55赫兹）典型频段的电生理学周期性成分。功率谱的非周期性成分通过模型偏移、膝关节和指数进行评估：我们发现，在正念冥想过程中，非癫痫患者颞叶中叶（MTL）内的伽马功率（30-55 Hz）与意念游荡相比明显下降（p = 1.20E-4），但癫痫患者颞叶中叶内的伽马功率却没有下降（p = 0.352）。在不同脑状态下，癫痫颞中叶 MTL 任何频段的功率均无明显变化。相反，在癫痫中颞叶内的非周期性成分（偏移、膝盖和指数，均为 p 0.70）中，思维游离和正念之间存在显著差异：意义：癫痫和非癫痫 MTL 的颅内电生理调节在大脑状态（思绪游荡与正念）之间可能存在差异。非癫痫性 MTL 中伽马活动的调节可能代表大脑状态的功能性变化，而癫痫性 MTL 中的非周期性变化可能调节癫痫发作的倾向。

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来源期刊

Epilepsy & Behavior 医学-行为科学

CiteScore

5.40

自引率

15.40%

发文量

385

审稿时长

43 days

期刊介绍： Epilepsy & Behavior is the fastest-growing international journal uniquely devoted to the rapid dissemination of the most current information available on the behavioral aspects of seizures and epilepsy. Epilepsy & Behavior presents original peer-reviewed articles based on laboratory and clinical research. Topics are drawn from a variety of fields, including clinical neurology, neurosurgery, neuropsychiatry, neuropsychology, neurophysiology, neuropharmacology, and neuroimaging. From September 2012 Epilepsy & Behavior stopped accepting Case Reports for publication in the journal. From this date authors who submit to Epilepsy & Behavior will be offered a transfer or asked to resubmit their Case Reports to its new sister journal, Epilepsy & Behavior Case Reports.