Epilepsy & Behavior最新文献

{"title":"Quality of life measure for children with Epilepsy: A psychometric evaluation of the Italian version","authors":"Carlotta Tagliaferro ,&nbsp;Elena Cavallini ,&nbsp;Pietro Cappelletto ,&nbsp;Chloe Lau ,&nbsp;Martina Preti ,&nbsp;Claudia Marino ,&nbsp;Simona Pellacani ,&nbsp;Gabriel M. Ronen ,&nbsp;Francesca Chiesi ,&nbsp;Carmen Barba","doi":"10.1016/j.yebeh.2025.110857","DOIUrl":"10.1016/j.yebeh.2025.110857","url":null,"abstract":"<div><h3>Objective</h3><div>To report on the Italian validation of the Child Epilepsy Quality of Life Questionnaire (CHEQOL-25), including both the child self-report and parent-proxy versions.</div></div><div><h3>Methods</h3><div>The validation procedure was conducted at a single Italian centre between July 2024 and July 2025, involving 252 children with epilepsy and their parents. A forward–backward translation process was carried out in line with established best-practice guidelines. Data collection included family interviews and medical chart reviews. Psychometric evaluation covered reliability and validity.</div></div><div><h3>Results</h3><div>All items exceeded the accepted thresholds (≥ 0.78) for both content validity and comprehensibility. The factor structure closely replicated the original five-factor model, with certain items showing stronger loadings than the original study within the <em>Interpersonal/Social</em> and <em>Intrapersonal/Emotional</em> domains in both related versions. The <em>Secrecy</em> factor showed greater variability (h² = 0.06–.83), possibly reflecting differences in parental interpretation or their sensitivity to the epilepsy concealment. Children who engaged in playful activities scored higher across most subscales, particularly in the <em>Interpersonal/Social</em> and the <em>Quest for Normality</em> domains of the self-report version. Importantly, children not receiving school support reported higher scores across several subscales, suggesting fewer perceived psychosocial challenges. Agreement between child self-reports and parent proxy-reports ranged from moderate to strong (ICC = 0.53–.71).</div></div><div><h3>Conclusions</h3><div>The Italian version of the <em>CHEQOL-25</em> measure demonstrates strong psychometric properties (consistent with the original version) and reinforces the value of assessing quality of life in children with epilepsy across diverse cultural contexts.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"175 ","pages":"Article 110857"},"PeriodicalIF":2.3,"publicationDate":"2025-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145734944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mind the Gap! What do people with epilepsy want to know?","authors":"Sarah Jones ,&nbsp;Heather Angus-Leppan","doi":"10.1016/j.yebeh.2025.110861","DOIUrl":"10.1016/j.yebeh.2025.110861","url":null,"abstract":"<div><h3>Background</h3><div>There is little research about the questions asked by people with epilepsy, and how these are answered. Information sources include standardised medical or charity websites, responses generated by artificial intelligence paradigms and informal peer support.</div></div><div><h3>Methods</h3><div>Through social media (X, formerly Twitter) people with epilepsy were asked “what would you ask a neurologist/epileptologist” and “do you have any questions relating to your epilepsy”. Responses were themed using an unsupervised topic modelling algorithm to categorise into an aggregated question set.<!--> <!-->Thematic qualitative analysis characterised emotional content and underlying patterns of the responses.</div></div><div><h3>Results</h3><div>Questions and responses were in English. There were 2752 responses from Europe, North America and Australia, in the format of natural language. 74% of the questions generated are not currently answered by verified sources. 83% centred on restrictions and limitations.</div></div><div><h3>Conclusions</h3><div>The study highlights a gap between the concerns of people with epilepsy and accurate, readily available information. The unsupervised topic modelling algorithm successfully grouped the questions into themes. Most questions focused on restrictions and loss of opportunities and enjoyment. These currently unanswered questions could lead people to rely on unverified information. The work highlights the need for evidence-based answers, and a focus on positive messages about what people with epilepsy can do to preserve autonomy and maximise quality of life. Future work will seek patient and carer questions in different languages and settings and develop systems to improve information provision for people with epilepsy.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"175 ","pages":"Article 110861"},"PeriodicalIF":2.3,"publicationDate":"2025-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145734942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dose adjustment of the anti-seizure medications levetiracetam and lamotrigine during the postpartum period. Schedule plan, safety and efficacy","authors":"Nadejda Khmelev ,&nbsp;Firas Fahoum ,&nbsp;Lilach Goldstein","doi":"10.1016/j.yebeh.2025.110858","DOIUrl":"10.1016/j.yebeh.2025.110858","url":null,"abstract":"<div><h3>Introduction</h3><div>Lamotrigine (LTG) and Levetiracetam (LEV) are anti-seizure medications (ASMs) widely used for treatment of women with epilepsy (WWE) of childbearing age due to low teratogenic potential. Physiological changes during gestation results in enhanced clearance. Drug level monitoring and frequent dose adjustments are required to avoid decline in serum levels and compromised seizure control. Postpartum, physiological changes reverse and ASM clearance trends back to pre-pregnancy rate. Rapid metabolic changes make drug level monitoring and dose adjustments challenging. A delay in dose decrement could result in toxicity. The optimal postpartum dose reduction rate hasn’t been established.</div></div><div><h3>Methods</h3><div>We retrospectively examined medical records of pregnant WWE followed at Tel Aviv Sourasky Medical Center from 2018 to 2023. Initially, patients were instructed to continue therapeutic drug monitoring (TDM) postpartum. Starting October 2020, an empiric taper regimen was implemented with dose adjustments scheduled 1, 7, and 21 days postpartum. Individualized regimens were provided during last prenatal visit. We recorded ASM dose, serum levels, seizure frequency, and side effects.</div></div><div><h3>Results</h3><div>Eighty-one pregnancies in 75 WWE were included. Forty-two were treated with LEV, 35 with LTG, and 4 with both. In 24 pregnancies patients continued TDM postpartum, and 57 followed empiric protocol. Among seizure-free WWE before and during pregnancy, none of 44 in the empiric group and 2 of 16 in TDM group had postpartum seizures. Side effects occurred in 6 of 54 empiric group and 5 of 21 TDM group.</div></div><div><h3>Conclusion</h3><div>Empiric postpartum tapering was not linked to increased seizure risk and was well tolerated.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"175 ","pages":"Article 110858"},"PeriodicalIF":2.3,"publicationDate":"2025-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145734943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Living with epilepsy: what characterizes the everyday life of adults with epilepsy in Western countries? A systematic synthesis of qualitative studies","authors":"Ellen Gabrielsen Hjelle ,&nbsp;Irma Pinxsterhuis ,&nbsp;Unni Sveen ,&nbsp;Line Kildal Bragstad","doi":"10.1016/j.yebeh.2025.110828","DOIUrl":"10.1016/j.yebeh.2025.110828","url":null,"abstract":"<div><h3>Background</h3><div>Epilepsy is a complex neurological disease affecting millions worldwide. Beyond seizure management, individuals with epilepsy face significant emotional, cognitive, and social challenges that impact their quality of life and societal participation. This qualitative systematic review explored the lived experiences of adults with epilepsy in Western countries, focusing on their participation in daily life.</div></div><div><h3>Methods</h3><div>A meta-aggregated synthesis was conducted, guided by the Joanna Briggs Institute’s recommendations. Sixteen qualitative studies published between 2016 and 2024 were included, representing 391 participants and 3,580 online posts.</div></div><div><h3>Results</h3><div>The three key themes: “Understanding the condition and the need for tailored information”, “self-management and support” and “stigma and the dilemma of disclosure or concealment” encompass multifaceted aspects of living with epilepsy. These include the disruptive and unpredictable nature of epilepsy, the critical role of personalized information in disease management, and the importance of effective coping and self-management strategies. Participants reported challenges such as stigma, discrimination, and difficulties in forming and maintaining relationships. Support from family, peers, and healthcare professionals was identified as critical but often insufficient. Stigma emerged as a pervasive issue, with many concealing their condition to avoid judgment, despite the risks. Public education and peer support were highlighted as essential to reducing stigma and fostering inclusion.</div></div><div><h3>Conclusions</h3><div>Living with epilepsy requires more than seizure management; it involves navigating a complex interplay of physical, emotional, and social challenges. A comprehensive approach including medication, individualized care, and support for lifestyle adjustments is recommended. Public education is suggested to reduce the stigma associated with epilepsy.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"175 ","pages":"Article 110828"},"PeriodicalIF":2.3,"publicationDate":"2025-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145734861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Driving habits and difficulties in people with epilepsy: A survey","authors":"Lucile Guillermier ,&nbsp;Cécile Sabourdy ,&nbsp;Emeline Four ,&nbsp;Nicolas Mezouar ,&nbsp;Laurence Paire-Ficout ,&nbsp;Maud Ranchet","doi":"10.1016/j.yebeh.2025.110824","DOIUrl":"10.1016/j.yebeh.2025.110824","url":null,"abstract":"<div><div>Epilepsy is a neurological condition that can interfere with driving abilities through seizures and cognitive impairments. While legal frameworks often regulate driving eligibility, little is known about how people with epilepsy perceive and adapt their driving in everyday life. This study aimed to examine driving habits, self-perceived difficulties, and adaptive behaviors in people with epilepsy compared to a control group. A total of 665 participants (103 individuals with epilepsy and 562 individuals without epilepsy) completed an online questionnaire covering driving habits, avoidance behaviors, and compensatory strategies. Statistical analyses were conducted to compare responses between groups. Contrary to expectations, individuals with epilepsy do not report more driving difficulties than controls. On the other hand, they appear to have more avoidance behavior and compensatory strategies. They were more likely to avoid certain situations (e.g., night driving, long trips) and to implement proactive adjustments (e.g., driving only when feeling well, taking shorter trips). People with epilepsy appear to implement self-regulation strategies that reduce their exposure to difficult driving conditions. These strategies likely help maintain safe driving practices but may also restrict mobility and autonomy. Given that these data are based on self-reports the interpretation of the results must be cautious, particularly since people with epilepsy did not report more difficulties than controls. We propose two interpretations (i.e., adaptive hypothesis and anticipatory hypothesis) that are not mutually exclusive. Future studies should integrate these perspectives with objective assessments to provide more robust evidence for clinical and regulatory recommendations.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"175 ","pages":"Article 110824"},"PeriodicalIF":2.3,"publicationDate":"2025-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145735018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disentangling deprivation: Differential associations of the area deprivation index- 3 factors with clinical, cognitive, and mood outcomes in epilepsy","authors":"Anny Reyes ,&nbsp;Jarrod E. Dalton ,&nbsp;Bruce P. Hermann ,&nbsp;Lisa Ferguson ,&nbsp;Imad M. Najm ,&nbsp;Robyn M. Busch","doi":"10.1016/j.yebeh.2025.110833","DOIUrl":"10.1016/j.yebeh.2025.110833","url":null,"abstract":"<div><h3>Objective</h3><div>Previous research utilizing neighborhood data has identified a three-factor structure underlying the Area Deprivation Index (ADI), a metric of neighborhood disadvantage. The three factors identified are Financial Strength, Economic Hardship and Inequality, and Educational Attainment. Here, we examine how these distinct dimensions of deprivation are associated with demographic and clinical characteristics, and mood and cognitive outcomes in patients with epilepsy.</div></div><div><h3>Methods</h3><div>Clinical, demographic, and neuropsychological data were obtained from an IRB-approved clinical registry in a cohort of 1,068 patients (age ≥ 16) with pharmacoresistant epilepsy evaluated for surgery at Cleveland Clinic (2000–2021). Neuropsychological measures assessed general abilities, verbal and nonverbal abilities, attention and working memory, processing speed, memory, language, executive function, and self-reported symptoms of depression and anxiety. Linear regressions were conducted to assess associations between ADI-3 factors and patient outcomes.</div></div><div><h3>Results</h3><div>Each ADI-3 factor had unique associations with demographic and clinical characteristics, including age, race, education, and epilepsy-related variables, including lower Financial Strength being associated with grater likely of the presence of mesial temporal sclerosis. Lower Financial Strength and Educational Attainment were linked to poorer performance across multiple cognitive domains, including general ability, verbal and nonverbal abilities, and working memory. Financial Strength remained a significant predictor of cognitive performance and greater depressive symptoms even after adjusting for demographic and clinical covariates.</div></div><div><h3>Discussion</h3><div>These findings support the multidimensional nature of neighborhood deprivation in an epilepsy surgical population and show that ADI-3 factors relate differently to key demographic, clinical, cognitive, and mood outcomes. Financial Strength was strongly and consistently linked to cognitive function and depressive symptoms, highlighting the value of analyzing specific deprivation domains. This approach allows for more precise identification of intervention targets and informs the development of targeted public health strategies to improve outcomes in epilepsy and other neurological conditions.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"175 ","pages":"Article 110833"},"PeriodicalIF":2.3,"publicationDate":"2025-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145734941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Wide range of cenobamate doses associated with initial seizure freedom in patients with uncontrolled focal seizures: Post-hoc analysis of a phase 3, multicenter, open-label study","authors":"William E. Rosenfeld ,&nbsp;Louis Ferrari","doi":"10.1016/j.yebeh.2025.110851","DOIUrl":"10.1016/j.yebeh.2025.110851","url":null,"abstract":"<div><h3>Objective</h3><div>To examine initial doses of cenobamate that were associated with seizure freedom (100% seizure reduction) in a subset of patients from a large, open-label, phase 3 safety study.</div></div><div><h3>Methods</h3><div>We reviewed available focal seizure efficacy data for patients (<em>N</em> = 240) from 10 eligible US study sites. Among patients achieving seizure freedom for ≥12 months (≥350 consecutive days) and ≥24 months (≥700 consecutive days) at last clinic visit, or at any time during the analysis, the doses of cenobamate at the start of their seizure-free interval were examined. We also examined cenobamate doses for ≥12-month and ≥24-month seizure freedom stratified by baseline seizure frequency (&lt; 3 vs ≥3 seizures/28 days).</div></div><div><h3>Results</h3><div>Of 62 patients with ≥12-month seizure freedom at their last visit, 24.2 % (15/62) of patients started their seizure-free interval at cenobamate doses ≤50 mg/day, 4.8 % (3/62) at 100 mg/day, 14.5 % (9/62) at 150 mg/day, and 12.9 % (8/62) at 200 mg/day. Of 33 patients who were seizure-free for ≥24 months at their last study visit, 45.5 % (15/33) started their seizure-free interval on cenobamate doses ≤ 50 mg/day, 3.0 % (1/33) at 100 mg/day, 15.2 % (5/33) at 150 mg/day, and 12.1 % (4/33) at 200 mg/day.</div></div><div><h3>Conclusion</h3><div>Of 62/240 patients achieving 12-month seizure freedom at last visit, 35/62 started their seizure-free interval at cenobamate doses ≤200 mg/day (24-month: 25/33). Attaining seizure freedom at a lower dose may be predictive of remaining seizure-free for a longer period. Further prospective research is needed to better define cenobamate’s efficacy at lower doses.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"175 ","pages":"Article 110851"},"PeriodicalIF":2.3,"publicationDate":"2025-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145734860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The whole-brain dynamic neuromagnetic network characteristics in childhood absence epilepsy: A multi-frequency magnetoencephalography study","authors":"Xinyi Zhou ,&nbsp;Jing Ning ,&nbsp;Yingfan Wang,&nbsp;Minghao Li,&nbsp;Jing Lu,&nbsp;Yinjie Zhu,&nbsp;Peilin Jiang,&nbsp;Ke Hu,&nbsp;Wenkang Li,&nbsp;Xiaoshan Wang","doi":"10.1016/j.yebeh.2025.110802","DOIUrl":"10.1016/j.yebeh.2025.110802","url":null,"abstract":"<div><h3>Objective</h3><div>This study was aimed to explore the mechanisms of seizure initiation, propagation, and termination in childhood absence epilepsy (CAE) by analyzing dynamic whole-brain network changes.</div></div><div><h3>Methods</h3><div>We recruited 37 unmedicated children with CAE and recorded magnetoencephalographic (MEG) data from 65 seizures and interictal periods. The seizure course was time-segmented, and a dynamic frequency analysis was conducted. Functional connectivity (FC) was assessed using corrected amplitude envelope correlation (AEC-c), and total node strengths were calculated based on AEC-c values.</div></div><div><h3>Results</h3><div>Total node strength exhibited distinct temporal and frequency-specific changes. Preictally, it increased in all frequency bands except alpha (P &lt; 0.05). Ictally, it decreased below interictal levels in the delta/theta bands but increased in all others (P &lt; 0.05). Postictally, it remained altered. Regarding FC, brain network reorganization began as early as the preictal phase. At seizure termination, beta synchronization declined first, while delta and gamma2 showed a transient peak.</div></div><div><h3>Conclusion</h3><div>This study characterized the dynamic reconfiguration of whole-brain functional networks across seizure phases in CAE, highlighting time- and frequency-specific changes.</div></div><div><h3>Significance</h3><div>By framing CAE as a network disorder, this study emphasized the importance of frequency-specific analyses in epilepsy research and provide insights to guide future frequency-targeted diagnostics and therapies.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"175 ","pages":"Article 110802"},"PeriodicalIF":2.3,"publicationDate":"2025-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145734926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel insights into cognitive network alterations in temporal lobe epilepsy: A [18F]SynVesT-1 PET study","authors":"Li Qin ,&nbsp;Bei Chen ,&nbsp;Ling Xiao ,&nbsp;Haoyue Zhu ,&nbsp;Manliu Hou ,&nbsp;Xiaoyan Long ,&nbsp;Weiting Tang ,&nbsp;Xiaobo Zhang ,&nbsp;Ming Qv ,&nbsp;Yongxiang Tang ,&nbsp;Zhimin Zhang ,&nbsp;Shuo Hu ,&nbsp;Li Feng","doi":"10.1016/j.yebeh.2025.110826","DOIUrl":"10.1016/j.yebeh.2025.110826","url":null,"abstract":"<div><h3>Background and objectives</h3><div>Current therapeutic interventions towards cognitive deficits in temporal lobe epilepsy (TLE) remain suboptimal due to incomplete elucidation of the underlying pathophysiological mechanisms. Emerging evidence implicates synapse loss as a critical neuropathological substrate associated with cognitive dysfunction. Given that synapse constitute the fundamental structural units of neural circuit and established disruption of cognitive networks in epilepsy, this study innovatively explores epileptic cognitive network alteration from synaptic viewpoint.</div></div><div><h3>Methods</h3><div>Utilizing [¹⁸F]SynVesT-1 positron emission tomography (PET) for in-vivo synaptic density quantification and Kullback-Leibler Divergence Similarity Estimation (KLSE) depicting for individual-level network characterization, we identified synaptic connectome alteration in TLE patients. The relationship between abnormal synaptic connectivity and cognitive assessment scores was evaluated by Spearman correlation analysis.</div></div><div><h3>Results</h3><div>We observed significant global reduction in edge connectivity and decreased weighted connectivity strength in TLE, which correlates with impaired neuropsychological performance in both intelligence and memory domains respectively. Hypoconnectivity in the frontal lobe and superior temporal gyrus correlated with poorer linguistic intelligence quotient (IQ). The caudate nucleus emerged as a critical hub, with its eigenvector centrality showing positive associations with both spatial skills and full-scale intelligence quotient (FSIQ). Hippocampal-posterior cortical circuitry involving the interaction between the hippocampus and the lingual gyrus, angular gyrus, calcarine fissure, mediated the variance in memory quotient (MQ).</div></div><div><h3>Conclusion</h3><div>These findings suggest that synaptic connectivity attenuation may serve as a novel biomarker for cognitive deficits in temporal lobe epilepsy, providing an innovative perspective for targeted clinical interventions.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"175 ","pages":"Article 110826"},"PeriodicalIF":2.3,"publicationDate":"2025-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145734927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transfer of Finnish adolescents with epilepsy to adult care: a population-based study","authors":"Matti L Sillanpää ,&nbsp;Vivian Reinhold ,&nbsp;Leevi Toivonen ,&nbsp;Peter R Camfield","doi":"10.1016/j.yebeh.2025.110856","DOIUrl":"10.1016/j.yebeh.2025.110856","url":null,"abstract":"<div><h3>Background</h3><div>Transferring adolescents with epilepsy (AWE) to adult care is a complex process, yet there is limited data on its overall epidemiology and clinical implications.</div></div><div><h3>Objective</h3><div>This population-based study analyzes the long-term clinical trajectories and predictors of transfer among AWE within a robust Finnish healthcare system.</div></div><div><h3>Methods</h3><div>A cohort of 439 AWE was followed for a mean of 10.28 years. Transfer outcomes, care settings, and long-term seizure control were evaluated for patients reaching transfer age, focusing on predictors of public adult specialty care.</div></div><div><h3>Results</h3><div>Of 222 AWE reaching transfer age, 189 (85.1 %) were transferred to adult services, with 64 % entering university hospital care. Remission was achieved in 23 % during extended follow-up, while 27 % remained drug-resistant. Multivariable analysis identified developmental and epileptic encephalopathy, specific developmental disorders, and comorbidities such as asthma, allergies, and obesity as significant predictors for public adult specialty care. Notably, changing the transfer age from 16 to 18 years had no significant effect on transfer rates.</div></div><div><h3>Conclusion</h3><div>Transfer to adult specialty care affects the vast majority of AWE, imposing considerable demands on public health systems. These findings underscore the need for early identification of high-risk patients to inform resource planning and individualized care strategies.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"175 ","pages":"Article 110856"},"PeriodicalIF":2.3,"publicationDate":"2025-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145734946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}