Clinical rationale for dietary lutein supplementation in long COVID and mRNA vaccine injury syndromes.

Q2 Pharmacology, Toxicology and Pharmaceutics F1000Research Pub Date : 2024-10-17 eCollection Date: 2024-01-01 DOI:10.12688/f1000research.143517.3
Anthony M Kyriakopoulos, Greg Nigh, Peter A McCullough, Stephanie Seneff
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Abstract

Lutein, a plant-derived xanthophyl-carotenoid, is an exceptional antioxidant and anti-inflammatory constituent found in food. High dietary intake of lutein is beneficial against eye disease, improves cardiometabolic health, protects from neurodegenerative diseases, and is beneficial for liver, kidney, and respiratory health. Lutein protects against oxidative and nitrosative stress, both of which play a major role in long COVID and mRNA vaccination injury syndromes. Lutein is an important natural agent for therapeutic use against oxidative and nitrosative stress in chronic illnesses such as cardiovascular and neurodegenerative diseases and cancer. It can also potentially inhibit spike protein-induced inflammation. Rich dietary supplementation of lutein, naturally derived in non-biodegradable Extra Virgin Olive Oil (EVOO), can most optimally be used against oxidative and nitrosative stress during post-COVID and mRNA vaccination injury syndromes. Due to its high oleic acid (OA) content, EVOO supports optimal absorption of dietary lutein. The main molecular pathways by which the SARS-CoV-2 spike protein induces pathology, nuclear factor kappa-light-chain-enhancer activated B cells (NF-κB) and activated protein (AP)-1, can be suppressed by lutein. Synergy with other natural compounds for spike protein detoxification is likely.

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在长 COVID 和 mRNA 疫苗损伤综合征中补充叶黄素的临床依据。
叶黄素是一种源自植物的类黄酮-类胡萝卜素,是食物中一种特殊的抗氧化和抗炎成分。从膳食中摄入大量叶黄素有益于防治眼疾,改善心脏代谢健康,预防神经退行性疾病,有益于肝脏、肾脏和呼吸系统健康。叶黄素可防止氧化应激和亚硝酸应激,这两种应激在长 COVID 和 mRNA 疫苗接种损伤综合症中都起着重要作用。叶黄素是一种重要的天然药物,可用于治疗心血管疾病、神经退行性疾病和癌症等慢性疾病中的氧化应激和亚硝酸应激。它还有可能抑制尖峰蛋白诱发的炎症。叶黄素是在不可生物降解的特级初榨橄榄油(EVOO)中天然提取的,从膳食中补充叶黄素可以最有效地应对 COVID 和 mRNA 疫苗接种后损伤综合症中的氧化应激和亚硝酸应激。由于其油酸 (OA) 含量高,EVOO 可支持膳食中叶黄素的最佳吸收。叶黄素可抑制 SARS-CoV-2 穗状病毒蛋白诱导病理学的主要分子途径--核因子卡巴轻链增强活化 B 细胞(NF-κB)和活化蛋白(AP)-1。叶黄素很可能与其他天然化合物协同作用,为尖峰蛋白解毒。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
F1000Research
F1000Research Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (all)
CiteScore
5.00
自引率
0.00%
发文量
1646
审稿时长
1 weeks
期刊介绍: F1000Research publishes articles and other research outputs reporting basic scientific, scholarly, translational and clinical research across the physical and life sciences, engineering, medicine, social sciences and humanities. F1000Research is a scholarly publication platform set up for the scientific, scholarly and medical research community; each article has at least one author who is a qualified researcher, scholar or clinician actively working in their speciality and who has made a key contribution to the article. Articles must be original (not duplications). All research is suitable irrespective of the perceived level of interest or novelty; we welcome confirmatory and negative results, as well as null studies. F1000Research publishes different type of research, including clinical trials, systematic reviews, software tools, method articles, and many others. Reviews and Opinion articles providing a balanced and comprehensive overview of the latest discoveries in a particular field, or presenting a personal perspective on recent developments, are also welcome. See the full list of article types we accept for more information.
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