Implementation of an EOS calculator-based protocol decreased infant antibiotic exposure in chorioamnionitis without correlation with placental histopathology.

IF 2.4 3区医学 Q2 OBSTETRICS & GYNECOLOGY Journal of Perinatology Pub Date : 2024-11-09 DOI:10.1038/s41372-024-02167-z

Tonya Robinson, Kimberly Knott, Zhanxu Liu, Maiying Kong, Sucheta Telang

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Abstract

Objective: To determine the impact of the Early Onset Sepsis (EOS) calculator on antibiotic exposure in infants born to mothers with clinical chorioamnionitis and correlate EOS calculator-guided recommendations with placental histopathology.

Study design: Retrospective observational study comparing infants ≥ 36 weeks gestation exposed to maternal clinical chorioamnionitis admitted to the neonatal intensive care unit (NICU) before (Group 1, n = 69) and after (Group 2, n = 139) implementation of an EOS calculator protocol for chorioamnionitis. Infant antibiotic exposure and placental pathology were reviewed. Comparisons were made using Mann-Whitney and chi-square tests.

Results: There was a statistically significant decrease in antibiotic exposure from Group 1 to Group 2 (p < 0.001) with no EOS cases missed. No correlation was found between EOS calculator-based treatment and participant placental histopathology (p = 0.966).

Conclusion: Implementation of an EOS calculator protocol specific to our study population reduced antibiotic exposure. No correlations were found between EOS calculator-based antibiotic treatment and histological chorioamnionitis.

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实施基于 EOS 计算器的方案可减少绒毛膜羊膜炎婴儿的抗生素暴露量，但与胎盘组织病理学无关。

目的确定早期脓毒症（EOS）计算器对临床绒毛膜羊膜炎母亲所生婴儿抗生素暴露的影响，并将EOS计算器指导建议与胎盘组织病理学相关联：回顾性观察研究：比较在新生儿重症监护病房（NICU）住院的妊娠≥36周、患有临床绒毛膜羊膜炎的母亲的婴儿在实施绒毛膜羊膜炎EOS计算器方案之前（第1组，n = 69）和之后（第2组，n = 139）的抗生素暴露情况。对婴儿抗生素暴露和胎盘病理学进行了回顾。采用曼-惠特尼检验和卡方检验进行比较：结果：从第 1 组到第 2 组，抗生素暴露量有明显的统计学下降（p 结论：从第 1 组到第 2 组，抗生素暴露量有明显的统计学下降：针对我们的研究人群实施的 EOS 计算器方案减少了抗生素暴露量。基于 EOS 计算器的抗生素治疗与组织学绒毛膜羊膜炎之间没有相关性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Perinatology 医学-妇产科学

CiteScore

5.40

自引率

6.90%

发文量

284

审稿时长

3-8 weeks

期刊介绍： The Journal of Perinatology provides members of the perinatal/neonatal healthcare team with original information pertinent to improving maternal/fetal and neonatal care. We publish peer-reviewed clinical research articles, state-of-the art reviews, comments, quality improvement reports, and letters to the editor. Articles published in the Journal of Perinatology embrace the full scope of the specialty, including clinical, professional, political, administrative and educational aspects. The Journal also explores legal and ethical issues, neonatal technology and product development. The Journal’s audience includes all those that participate in perinatal/neonatal care, including, but not limited to neonatologists, perinatologists, perinatal epidemiologists, pediatricians and pediatric subspecialists, surgeons, neonatal and perinatal nurses, respiratory therapists, pharmacists, social workers, dieticians, speech and hearing experts, other allied health professionals, as well as subspecialists who participate in patient care including radiologists, laboratory medicine and pathologists.