Rat Hepatitis E Virus Isolates Cluster among Urban Norway Rats (Rattus norvegicus) across a Roadway.

IF 1.1 4区农林科学 Q3 VETERINARY SCIENCES Journal of Wildlife Diseases Pub Date : 2024-11-11 DOI:10.7589/JWD-D-24-00052

Elly M Blake, Kaylee A Byers, Michael Joseph Lee, Jingxin Cao, Christine Layne, Jamie Borlang, Denise Huynh, Anton Andonov, Kevin Kuchinski, Jessie Lynch, Sarah J Robinson, Anne-Marie Nicol, Chelsea G Himsworth

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Abstract

Hepatitis E virus (HEV) is a globally distributed pathogen that causes acute hepatitis in people. Recent human cases of HEV arising after contact with urban rats (Rattus spp.) have raised concerns regarding whether rats may be a source of HEV infection. We investigated whether urban Norway rats (Rattus norvegicus) could be a source of HEV in an underserved urban neighborhood of Vancouver, Canada. We found that 15% of rats tested positive for rat HEV, and that HEV status was associated with increasing rat body length and family relationships. Rat HEV isolates were clustered according to their location on either the east or west side of a busy roadway bisecting this neighborhood, suggesting that this street is a barrier to HEV spread. Widespread distribution of HEV among rats in this neighborhood poses potential human health risks, emphasizing the need to reduce close contact of people with rats and their excreta.

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大鼠戊型肝炎病毒分离株在城市挪威鼠（Rattus norvegicus）中跨道路聚集。

戊型肝炎病毒（HEV）是一种分布于全球的病原体，可导致急性肝炎。最近，人类因接触城市老鼠（Rattus spp.）而感染戊型肝炎病毒的病例引起了人们对老鼠是否可能成为戊型肝炎病毒感染源的关注。我们在加拿大温哥华一个服务不足的城市社区调查了城市挪威鼠（Rattus norvegicus）是否会成为 HEV 的传染源。我们发现，15% 的老鼠对老鼠 HEV 检测呈阳性，而 HEV 状态与老鼠体长和家庭关系的增加有关。大鼠 HEV 分离物根据其所在位置的不同而聚集在将该社区一分为二的繁忙道路的东侧或西侧，这表明这条街道是 HEV 传播的障碍。HEV 在该社区老鼠中的广泛分布给人类健康带来了潜在风险，因此有必要减少人类与老鼠及其排泄物的密切接触。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Wildlife Diseases 农林科学-兽医学

CiteScore

2.70

自引率

0.00%

发文量

213

审稿时长

6-16 weeks

期刊介绍： The JWD publishes reports of wildlife disease investigations, research papers, brief research notes, case and epizootic reports, review articles, and book reviews. The JWD publishes the results of original research and observations dealing with all aspects of infectious, parasitic, toxic, nutritional, physiologic, developmental and neoplastic diseases, environmental contamination, and other factors impinging on the health and survival of free-living or occasionally captive populations of wild animals, including fish, amphibians, reptiles, birds, and mammals. Papers on zoonoses involving wildlife and on chemical immobilization of wild animals are also published. Manuscripts dealing with surveys and case reports may be published in the Journal provided that they contain significant new information or have significance for better understanding health and disease in wild populations. Authors are encouraged to address the wildlife management implications of their studies, where appropriate.